التفاصيل البيبلوغرافية
| العنوان: |
2‐Amino‐4‐arylthiophene‐3‐carbonitrile and formamidine acetate as key building units for the synthesis of 5‐arylthieno[2,3‐d]pyrimidin‐4‐amines. |
| المؤلفون: |
Alizadeh‐Bami, Farzaneh1 (AUTHOR), Mehrabi, Hossein1 (AUTHOR) h.mehrabi@vru.ac.ir, Hosseini‐pour, Maryam1 (AUTHOR) |
| المصدر: |
Journal of Heterocyclic Chemistry. Nov2023, Vol. 60 Issue 11, p1883-1893. 11p. |
| مصطلحات موضوعية: |
*FORMAMIDINES, *ACETATES, *CONDENSATION, *SOLVENTS |
| مستخلص: |
We tried to establish a method for the synthesis of 5‐arylthieno[2,3‐d]pyrimidin‐4‐amine analogues via three‐step reactions and examined the changes in the solvent, time, and temperature. A novel condition has been developed for the preparation of substituted 2‐aminothiophenes employing the Knoevenagel condensation followed by the Gewald method and in the last step to form thieno[2,3‐d]pyrimidines by using formamidine acetate. All the synthesized 5‐arylthieno[2,3‐d]pyrimidin‐4‐amines are unknown and were characterized by IR, 1H‐NMR, 13C‐NMR, and CHN analysis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |