التفاصيل البيبلوغرافية
| العنوان: |
Combining the Peptide RWQWRWQWR and an Ethanolic Extract of Bidens pilosa Enhances the Activity against Sensitive and Resistant Candida albicans and C. auris Strains. |
| المؤلفون: |
Vargas-Casanova, Yerly1 (AUTHOR) y.vargasc@javeriana.edu.co, Bravo-Chaucanés, Claudia Patricia1 (AUTHOR) claub06@gmail.com, Martínez, Andrea Ximena Hernández2 (AUTHOR) hernandez_a@javeriana.edu.co, Costa, Geison Modesti2 (AUTHOR) modesticosta.g@javeriana.edu.co, Contreras-Herrera, Jorge Luis3 (AUTHOR) jorge.contreras@itp.edu.co, Medina, Ricardo Fierro4 (AUTHOR) rfierrom@unal.edu.co, Rivera-Monroy, Zuly Jenny4 (AUTHOR) zjriveram@unal.edu.co, García-Castañeda, Javier Eduardo4 (AUTHOR) jaegarciaca@unal.edu.co, Parra-Girado, Claudia Marcela1 (AUTHOR) claudia.parra@javeriana.edu.co |
| المصدر: |
Journal of Fungi. Aug2023, Vol. 9 Issue 8, p817. 28p. |
| مصطلحات موضوعية: |
*PEPTIDES, *CANDIDA albicans, *DEFORMATION of surfaces, *CELL morphology, *PEPTIDE derivatives, *ANTIFUNGAL agents |
| مستخلص: |
The antifungal activity of palindromic peptide RWQWRWQWR and its derivatives was evaluated against clinical isolates of Candida albicans and C. auris. Also, Bidens pilosa ethanolic extracts of leaves and stem were evaluated. Furthermore, combinations of peptide, extract, and/or fluconazole (FLC) were evaluated. The cytotoxicity of peptides and extracts in erythrocytes and fibroblasts was determined. The original palindromic peptide, some derivative peptides, and the ethanolic extract of leaves of B. pilosa exhibited the highest activity in some of the strains evaluated. Synergy was obtained between the peptide and the FLC against C. auris 435. The combination of the extract and the original palindromic peptide against C. albicans SC5314, C. auris 435, and C. auris 537 decreased the minimal inhibitory concentrations (MICs) by a factor of between 4 and 16. These mixtures induced changes in cell morphology, such as deformations on the cell surface. The results suggest that the combination of RWQWRWQWR and B. pilosa extract is an alternative for enhancing antifungal activity and decreasing cytotoxicity and costs and should be considered to be a promising strategy for treating diseases caused by Candida spp. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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