التفاصيل البيبلوغرافية
| العنوان: |
Iodine/Sulfinates: Rapid and Convenient Thiolation of Imidazo Heterocycles without Additives. |
| المؤلفون: |
Redon, Sébastien1 (AUTHOR) sebastien.redon@univ-amu.fr, Mendes, Anne-Sophie1 (AUTHOR), Vanelle, Patrice1 (AUTHOR) patrice.vanelle@univ-amu.fr |
| المصدر: |
Synlett. Sep2023, Vol. 34 Issue 14, p1723-1726. 4p. |
| مصطلحات موضوعية: |
*IODINE, *SULFINATES, *HETEROCYCLIC compounds, *METHOXY group, *MICROWAVE heating |
| مستخلص: |
Keywords: sulfinate; sulfenylation; iodine; microwave heating; heterocycles; thiolation EN sulfinate sulfenylation iodine microwave heating heterocycles thiolation 1723 1726 4 08/18/23 20230901 NES 230901 Graph Organic sulfur compounds, especially thioethers, are prominent structural motifs in many bioactive natural products, pharmaceuticals, materials, and agrochemicals. [7] In 2018, the Song group developed a difunctionalization of an imidazopyridine by using a sodium sulfinate and iodine (Scheme 1)..[8] With the base and iodine, they obtained the sulfonylated product exclusively, whereas with iodine and a reducing agent (PPh SB 3 sb ), they obtained the sulfenylated product exclusively. However, the reaction of B 1a b with B 2a b in Et SB 2 sb O as a solvent under basic conditions at 100 °C for 20 hours gave the 3-phenylsulfonylated product B 4a b in only 50% conversion, along with 50% of the 3-iodo compound B 5 b (Table 1, entry 1). [Extracted from the article] |
| قاعدة البيانات: |
Academic Search Index |