التفاصيل البيبلوغرافية
| العنوان: |
Effect of fermented Rhus verniciflua stokes extract on liver function parameters in healthy Korean adults: a double-blind randomized controlled trial. |
| المؤلفون: |
Kwak, Jung Hyun1 (AUTHOR), Lee, Hyo-Jeong2 (AUTHOR), Jeong, Seok-Tae3 (AUTHOR), Lee, Ju Yeon1 (AUTHOR), Lee, Minho4 (AUTHOR), Paik, Jean Kyung1 (AUTHOR) jkpaik@eulji.ac.kr |
| المصدر: |
Trials. 11/22/2021, Vol. 22 Issue 1, p1-10. 10p. 6 Charts. |
| مصطلحات موضوعية: |
*KOREANS, *TOXICODENDRON vernicifluum, *RANDOMIZED controlled trials, *BLOOD lipids, *LIVER |
| مستخلص: |
Background: Fermented Rhus verniciflua Stokes extract (FRVE) reported an anti-hepatic lipidemic property mediated by the upregulation of AMP-activated protein kinase (AMPK) in cell and animal models. However, it remains unclear whether there is an effect of FRVE on liver disease-related parameters and serum lipid levels in humans. We investigated the effects of FRVE intake for 12 weeks on liver disease-related parameters and serum lipid profiles in Korean adults.Methods: A randomized, double-blind, placebo-controlled study was conducted among 79 subjects. An aqueous extract of fermented Rhus verniciflua Stokes that was filtered and fermented was prepared. For 12 weeks, the test group (n = 39) consumed two capsules of FRVE (main components: fustin 129 mg and fisetin 59 mg) once daily. The control group (n = 40) consumed two placebo pills (main component: lactose 627.0 mg) once daily. A 1:1 randomization of control and test was performed using computer-generated randomization. Both before and after FRVE intake, anthropometric parameters, liver function-related parameters, and clinical laboratory parameters were measured. The effects between the test and control groups were compared using the Mann-Whitney U test and independent t-test, and the difference between baseline and follow-up values was compared using Wilcoxon rank-sum test and paired t-test.Results: There was no significant difference when comparing the change values of liver disease-related parameters and serum lipid profiles in between groups.Conclusions: In our study, we did not confirm the significance in liver function parameters and serum lipid profiles.Trial Registration: The study protocol was registered in the Clinical Research Information Service (CRIS: https://cris.nih.go.kr/cris/index.jsp ) under number KCT0005687. Registered on 2 December 2020. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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