التفاصيل البيبلوغرافية
| العنوان: |
VRK-1 extends life span by activation of AMPK via phosphorylation. |
| المؤلفون: |
Sangsoon Park1, Artan, Murat1, Seung Hyun Han2, Park, Hae-Eun H.3, Yoonji Jung3, Hwang, Ara B.1, Won Sik Shin2, Kyong-Tai Kim1,2 ktk@postech.ac.kr, Lee, Seung-Jae V.3 seungjaevlee@kaist.ac.kr |
| المصدر: |
Science Advances. 7/1/2020, Vol. 6 Issue 27, p1-13. 13p. |
| مصطلحات موضوعية: |
*LONGEVITY, *LIFE spans, *LIFE sciences, *PHYSIOLOGY, *NUCLEOPROTEINS, *SERINE/THREONINE kinases, *P53 protein |
| مستخلص: |
The article offers information about the vaccinia virus–related kinase (VRK) as an evolutionarily conserved nuclear protein kinase. It discusses the role of VRK-1 in post-mitotic cells and adult life span. It shows how VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. |
| قاعدة البيانات: |
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