التفاصيل البيبلوغرافية
| العنوان: |
Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles. |
| المؤلفون: |
Babos, György1,2 babos@mukki.richem.hu, Biró, Emese1,2, Meiczinger, Mónika2, Feczkó, Tivadar1,2 tivadar.feczko@gmail.com |
| المصدر: |
Polymers (20734360). Aug2018, Vol. 10 Issue 8, p895. 1p. 1 Diagram, 3 Charts, 5 Graphs. |
| مصطلحات موضوعية: |
*CANCER treatment, *DRUG delivery systems, *SORAFENIB, *DOXORUBICIN, *POLYETHYLENE glycol, *NANOMEDICINE, *POLYLACTIC acid |
| مستخلص: |
Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single-agent drugs, doxorubicin and sorafenib, against hepatocellular carcinoma. Biocompatible and biodegradable polymeric nanoparticles provide a promising approach for controlled drug release. In this study, doxorubicin and sorafenib with completely different chemical characteristics were simultaneously entrapped by the same polymeric carrier, namely poly(d,l-lactide-co-glycolide) (PLGA) and polyethylene glycol-poly(d,l-lactide-co-glycolide) (PEG-PLGA), respectively, using the double emulsion solvent evaporation method. The typical mean diameters of the nanopharmaceuticals were 142 and 177 nm, respectively. The PLGA and PEG-PLGA polymers encapsulated doxorubicin with efficiencies of 52% and 69%, respectively, while these values for sorafenib were 55% and 88%, respectively. Sustained drug delivery under biorelevant conditions was found for doxorubicin, while sorafenib was released quickly from the PLGA-doxorubicin-sorafenib and PEG-PLGA-doxorubicin-sorafenib nanotherapeutics. [ABSTRACT FROM AUTHOR] |
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