التفاصيل البيبلوغرافية
| العنوان: |
Surface charges promote nonspecific nanoparticle adhesion to stiffer membranes. |
| المؤلفون: |
Sinha, Shayandev1, Jing, Haoyuan1, Sachar, Harnoor Singh1, Das, Siddhartha1 |
| المصدر: |
Applied Physics Letters. 4/16/2018, Vol. 112 Issue 16, pN.PAG-N.PAG. 5p. |
| مصطلحات موضوعية: |
*ELECTRIC properties of cell membranes, *CELL membrane models, *ADHESION, *NANOPARTICLES, *NANOPARTICLE synthesis |
| مستخلص: |
This letter establishes the manner in which the electric double layer induced by the surface charges of the plasma membrane (PM) enhances the nonspecific adhesion (NSA) of a metal nanoparticle (NP) to stiffer PMs (i.e., PMs with larger bending moduli). The NSA is characterized by the physical attachment of the NP to the membrane and occurs when the decrease in the surface energy (or any other mechanism) associated with the attachment process provides the energy for bending the membrane. Such an attachment does not involve receptor-ligand interactions that characterize the specific membrane-NP adhesion. Here, we demonstrate that a significant decrease in the electrostatic energy caused by the NP-attachment-induced destruction of the charged-membrane-electrolyte interface is responsible for providing the additional energy needed for bending the membrane during the NP adhesion to stiffer membranes. A smaller salt concentration and a larger membrane charge density augment this effect, which can help to design drug delivery to cells with stiffer membranes due to pathological conditions, fabricate NPs with biomimetic cholesterol-rich lipid bilayer encapsulation, etc. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |