التفاصيل البيبلوغرافية
| العنوان: |
Role of the Axon Initial Segment in the Control of Spontaneous Frequency of Nigral Dopaminergic Neurons In Vivo. |
| المؤلفون: |
Meza, Rodrigo C.1,2, López-Jury, Luciana1,3, Canavier, Carmen C.3 ccanav@lsuhsc.edu, Henny, Pablo1 phenny@uc.cl |
| المصدر: |
Journal of Neuroscience. 1/17/2018, Vol. 38 Issue 3, p733-744. 12p. |
| مصطلحات موضوعية: |
*AXONS, *DOPAMINE analysis, *NEURON analysis, *DENDRITIC cells, *LYMPHOID tissue, *DENDRITIC crystals |
| مستخلص: |
The spontaneous tonic discharge activity of nigral dopamine neurons plays a fundamental role in dopaminergic signaling. To investigate the role of neuronal morphology and architecture with respect to spontaneous activity in this population, we visualized the 3D structure of the axon initial segment (AIS) along with the entire somatodendritic domain of adult male mouse dopaminergic neurons, previously recorded in vivo. We observed a positive correlation of the firing rate with both proximity and size of the AIS. Computational modeling showed that the size of the AIS, but not its position within the somatodendritic domain, is the major causal determinant of the tonic firing rate in the intact model, by virtue of the higher intrinsic frequency of the isolated AIS. Further mechanistic analysis of the relationship between neuronal morphology and firing rate showed that dopaminergic neurons function as a coupled oscillator whose frequency of discharge results from a compromise between AIS and somatodendritic oscillators. Thus, morphology plays a critical role in setting the basal tonic firing rate, which in turn could control striatal dopaminergic signaling that mediates motivation and movement. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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