التفاصيل البيبلوغرافية
| العنوان: |
Design and development of microemulsion drug delivery system of felodipine for improvement of oral bioavailability. |
| المؤلفون: |
Verma, Rinku1 rinku.cip@gmail.com, Darwhekar, G. N.1, Gupta, Ashish1, Sharma, Praveen1 |
| المصدر: |
International Journal of Pharmacy & Life Sciences. Apr2017, Vol. 8 Issue 4, p5511-5517. 7p. |
| مصطلحات موضوعية: |
*DRUG delivery systems, *MICROEMULSIONS, *PARTICLE size determination, *FELODIPINE, *EXCIPIENTS |
| مستخلص: |
Microemulsion drug delivery system is a novel and versatile approach for overcoming the formulation difficulties of drugs with poor aqueous solubility. The main purpose of this work was to develop an oral microemulsion formulation for enhancing the bioavailability of felodipine. Felodipine is a antihypertensive drug a calcium channel blocker it belongs to BCS class II. It shows extensive first pass metabolism. The bioavailability of felodipine is 15% hence it was suitable candidate for design microemulsion. The solubility of drug was determined in various oils, surfactants and cosurfactants for selection of components of formulations. Pseudo ternary phase diagram is a useful and important tool to study the phase behaviour of microemulsions Pseudo-ternary phase diagrams were constructed to obtain the appropriate components and their concentration ranges that result in large existence area of microemulsion. Microemulsion was prepared with 6%Isopropyl Myristate(IPM), 30% Tween 80&10% PEG-400 and 54% water respectively. Phase behaviour of the selected components was investigated by construction of ternary phase diagrams. Optimized formulation was evaluated for drug content, zeta potential, droplet size, pH, viscosity, in-vitro drug release profile and stability study. Globule size of optimize batch F3 was found to be 77.57nm. In vitro release study had shown 85.34% drug release from microemulsion which was more compared to pure drug suspension (55.1%). [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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