التفاصيل البيبلوغرافية
| العنوان: |
Maprotiline inhibits LPS-induced expression of adhesion molecules (ICAM-1 and VCAM-1) in human endothelial cells. |
| المؤلفون: |
Rafiee, Laleh1, Hajhashemi, Valiollah2 vhajhashemi@gmail.com, Javanmard, Shaghayegh Haghjooy3 |
| المصدر: |
Research in Pharmaceutical Sciences. Mar/Apr2016, Vol. 11 Issue 2, p138-144. 7p. |
| مصطلحات موضوعية: |
*MAPROTILINE, *ADRENERGIC uptake inhibitors, *ENDOTHELIAL cells |
| مستخلص: |
Regardless of the known anti-inflammatory potential of heterocyclic antidepressants, the mechanisms concerning their modulating effects are not completely known. In our earlier work, maprotiline, a heterocyclic antidepressants, considerably inhibited infiltration of polymorphonuclear cell leucocytes into the inflamed paw. To understand the mechanism involved, we evaluated the effect of vascular cell adhesion molecule (VCAM-1), intracellular adhesion molecule (ICAM-1) expression in stimulated endothelial cells. Endothelial cells were stimulated with lipopolysaccharide (LPS) in the presence and absence of maprotiline (10-8 to 10-6 M) and ICAM-1 and VCAM-1 expression were measured using real-time quantitative reverse transcription polymerase chain reaction. Maprotiline significantly decreased the LPS-induced expression of VCAM-1 at all applied concentrations. The expression of ICAM-1 decreased in the presence of maprotiline at 10-6 M concentration (P<0.05). Since maprotiline inhibits the expression of adhesion molecules, ICAM-1 and VCAM-1 in LPS-stimulated human endothelial cells, it can be a possible way through which maprotiline exerts its anti-inflammatory properties. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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