التفاصيل البيبلوغرافية
| العنوان: |
Comparison of oral dydrogesterone with vaginal progesteronefor luteal support in IUI cycles: A randomized clinical trial (RCT). |
| المؤلفون: |
Khosravi D.1, Taheripanah R.1 taheripanahf@gmail.com, Khosravi R.1, Taheripanah A.2, Tarighat Monfared V.1, Defaee S.1, Mehdighalb S.1, Hosseini Zijoud S. M.3 |
| المصدر: |
Iranian Journal of Reproductive Medicine. Apr2015 Supplement, p76-77. 2p. |
| مصطلحات موضوعية: |
*INFERTILITY, *PROGESTERONE, *CLINICAL trials, *ABORTION, *CYCLOGENESIS |
| مستخلص: |
Introduction: Progesterone supplementation is the first line of treatment in ovarian stimulation. This study was conduct to compare the effect of oral dydrogestrone with vaginal cyclogest on luteal phase support in intrauterine insemination (IUI) cycles. Material and methods: This prospective, randomized, double blind study was performed in a local infertility center from May 2013-2014. It consisted of 150 infertile women younger than 35 years old undergoing ovarian stimulation for IUI cycles. They underwent ovarian stimulation with oral dydrogesterone (20 mg) as group A and vaginal cyclogest (400 mg) as group B in preparation for the IU1 cycle. Clinical pregnancy and abortion rates, mid luteal progesterone (7 days after 1U1) and patients' satisfaction were compared between the two groups. Results: The mean serum progesterone levels was significantly higher in group A compared to group B (p=0.001). Pregnancy rate in group A was not statistically different from group B (p=0.58). Abortion rate in group B was higher than this rate in group A, but the difference was not statistically significant (p=0.056). Satisfaction rates were significantly higher in group A compare to group B (p<0.001). Conclusion: We concluded that oral dydrogestrone is as effective as vaginal progesterone for luteal-phase support in woman undergoing IUI cycles. Moreover, the mean serum progesterone levels and satisfaction rates in dydrogestrone group were higher than cyclogest group. [ABSTRACT FROM AUTHOR] |
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