HPLC methods for clinical pharmaceutical analysis : a user's guide /
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | كتاب |
| اللغة: | English |
| منشور في: |
Weinheim :
Wiley-VCH,
c2012.
|
| الطبعة: | 1st ed. |
| الموضوعات: | |
| الوصول للمادة أونلاين: | Contributor biographical information |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
جدول المحتويات:
- 1.Introduction
- 1.1.First Question: Determination of Ibuprofen in Plasma
- 1.2.Second Question: Determination of Tryptophan in Urine
- 1.3.Third Question: Determination of Paclitaxel in Tissue
- 2.Planning of Analyses
- 2.1.Introduction
- 2.2.Limit of Detection (LOD) and Determination (LLOQ)
- 2.3.Detectors
- 2.4.Structure of the Analyte
- 2.5.Solubility of an Analyte
- 2.6.Selection of the Detector
- 3.Sample Preparation
- 3.1.Dilution
- 3.2.Protein Precipitation, Overview
- 3.3.Extraction
- 4.HPLC Separation
- 4.1.HPLC Pumps
- 4.2.Degasser
- 4.3.Injector
- 4.4.HPLC Columns
- 5.Detection
- 5.1.Detection in the Pharmaceutical/Bioanalytical Area
- 5.2.Detection in the "Clinical Area" (Therapy Control/Compliance)
- 6.Chemical Derivatization for Detection Enhancement
- 7.Validation Concepts
- 7.1.Introduction
- 7.2.Realization of the FDA Guideline
- 8.Practical Hints Concerning Stability, Destruction and Degradation Products
- 9.Metabolites
- 10.Internal Standards
- 11.Case Studies with Intensive Discussion for Each Substance
- 11.1.Acetylcarnitine in Plasma
- 11.2.Acetylcysteine in Plasma
- 11.3.Acyclovir in Plasma and Urine
- 11.4.Caffeine in Plasma
- 11.5.Diazepam in Plasma
- 11.6.Diclofenac in Plasma
- 11.7.Dihydralazine in Plasma
- 11.8.Duramycin (Moli1901) in Plasma
- 11.9.Fluticasone Propionate in Plasma
- 11.10.Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine
- 11.11.Ibuprofen in Plasma (also Enantiomeric Separation)
- 11.12.Minocycline in Plasma
- 11.13.Norfloxacine in Plasma and Urine
- 11.14.Paclitaxel in Plasma, Urine and Tissue
- 11.15.Paracetamol (Acetaminophen) in Plasma
- 11.16.Pimelic Acid in Plasma and Urine
- 11.17.8-Prenylnaringenin in Plasma and Different Types of Tissues
- 11.18.Silibinin in Plasma
- 11.19.Valnemulin in Plasma, Different Tissue Types and in Animal Feed
- 11.20.Vitamin B1 (Total Thiamine) in Plasma
- Table 11.1 Recommended books
- Table 11.2 Properties of substances
- Appendix
- Short Description of Determination for about 100 Substances
- Substances listed in the Appendix.