HPLC methods for clinical pharmaceutical analysis : a user's guide /
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | كتاب |
| اللغة: | English |
| منشور في: |
Weinheim :
Wiley-VCH,
c2012.
|
| الطبعة: | 1st ed. |
| الموضوعات: | |
| الوصول للمادة أونلاين: | Contributor biographical information |
| الوسوم: |
إضافة وسم
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| 003 | KWAREICT | ||
| 005 | 20220223063517.0 | ||
| 008 | 161006s2012 gw a b 001 0 eng d | ||
| 020 | |a 9783527331291 | ||
| 035 | |a (Kwareict) u29525 | ||
| 035 | |a (KWAREICT)u29525 | ||
| 040 | |c kwaretech | ||
| 082 | 0 | 4 | |a 615.1901 M H H |
| 100 | 1 | |a Mascher, Hermann. | |
| 245 | 1 | 0 | |a HPLC methods for clinical pharmaceutical analysis : |b a user's guide / |c Hermann Mascher. |
| 250 | |a 1st ed. | ||
| 260 | |a Weinheim : |b Wiley-VCH, |c c2012. | ||
| 300 | |a ix, 247 p. : |b ill. ; |c 25 cm. | ||
| 336 | |a txt |b txt | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a 1.Introduction -- 1.1.First Question: Determination of Ibuprofen in Plasma -- 1.2.Second Question: Determination of Tryptophan in Urine -- 1.3.Third Question: Determination of Paclitaxel in Tissue -- 2.Planning of Analyses -- 2.1.Introduction -- 2.2.Limit of Detection (LOD) and Determination (LLOQ) -- 2.3.Detectors -- 2.4.Structure of the Analyte -- 2.5.Solubility of an Analyte -- 2.6.Selection of the Detector -- 3.Sample Preparation -- 3.1.Dilution -- 3.2.Protein Precipitation, Overview -- 3.3.Extraction -- 4.HPLC Separation -- 4.1.HPLC Pumps -- 4.2.Degasser -- 4.3.Injector -- 4.4.HPLC Columns -- 5.Detection -- 5.1.Detection in the Pharmaceutical/Bioanalytical Area -- 5.2.Detection in the "Clinical Area" (Therapy Control/Compliance) -- 6.Chemical Derivatization for Detection Enhancement -- 7.Validation Concepts -- 7.1.Introduction -- 7.2.Realization of the FDA Guideline -- 8.Practical Hints Concerning Stability, Destruction and Degradation Products -- 9.Metabolites -- 10.Internal Standards -- 11.Case Studies with Intensive Discussion for Each Substance -- 11.1.Acetylcarnitine in Plasma -- 11.2.Acetylcysteine in Plasma -- 11.3.Acyclovir in Plasma and Urine -- 11.4.Caffeine in Plasma -- 11.5.Diazepam in Plasma -- 11.6.Diclofenac in Plasma -- 11.7.Dihydralazine in Plasma -- 11.8.Duramycin (Moli1901) in Plasma -- 11.9.Fluticasone Propionate in Plasma -- 11.10.Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine -- 11.11.Ibuprofen in Plasma (also Enantiomeric Separation) -- 11.12.Minocycline in Plasma -- 11.13.Norfloxacine in Plasma and Urine -- 11.14.Paclitaxel in Plasma, Urine and Tissue -- 11.15.Paracetamol (Acetaminophen) in Plasma -- 11.16.Pimelic Acid in Plasma and Urine -- 11.17.8-Prenylnaringenin in Plasma and Different Types of Tissues -- 11.18.Silibinin in Plasma -- 11.19.Valnemulin in Plasma, Different Tissue Types and in Animal Feed -- 11.20.Vitamin B1 (Total Thiamine) in Plasma -- Table 11.1 Recommended books -- Table 11.2 Properties of substances -- Appendix -- Short Description of Determination for about 100 Substances -- Substances listed in the Appendix. | |
| 650 | 0 | 4 | |a High performance liquid chromatography. |
| 650 | 0 | 4 | |a Drugs |x Analysis. |
| 650 | 0 | 4 | |a Pharmaceutical technology. |
| 856 | 4 | 2 | |3 Contributor biographical information |u http://www.loc.gov/catdir/enhancements/fy1210/2012392592-b.html |
| 942 | |2 ddc |c BOOK | ||
| 999 | |c 14548 |d 14548 | ||
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