التفاصيل البيبلوغرافية
| العنوان: |
The effect of favipiravir versus hydroxychloroquine on clinical and laboratory findings in COVID-19 in healthcare workers |
| المؤلفون: |
Turan, Derya Bayırlı, Menteş, Mehtap, Özel, Yıldıran, Şerefhanoğlu, Kıvanç, Aydoğan, Burcu, İbil, Neşe, Güneşdoğdu, Füsun, Orucova, Hijran Mammadova, Saltürk, Cüneyt, Çelik, Hakan |
| المصدر: |
Brazilian Journal of Infectious Diseases. January 2022 26(1) |
| بيانات النشر: |
Brazilian Society of Infectious Diseases, 2022. |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, Hydroxychloroquine, Favipiravir, Healthcare workers |
| الوصف: |
Objectives Comparative data on hydroxychloroquine and favipiravir, commonly used agents in the treatment of Coronavirus Disease-2019 (COVID-19), are still limited. In this study, it was aimed to compare treatment outcomes in healthcare workers with COVID-19 who were prospectively followed by the occupational health and safety unit. Methods A total of 237 healthcare-workers, diagnosed as mild or moderate COVID-19 between March 11, 2020 and January 1, 2021, were given hydroxychloroquine (n = 114) or favipiravir (n = 123). Clinical and laboratory findings were evaluated. Results The mean age of the patients was 33.4±11.5 years. The mean time to negative PCR was found to be significantly shorter in patients receiving favipiravir compared to the hydroxychloroquine group (10.9 vs. 13.9 days; p < 0.001). The rate of hospitalization in the hydroxychloroquine group was significantly higher than favipiravir group (15.8% vs. 3.3%). In terms of side effects; the frequency of diarrhea in patients receiving hydroxychloroquine was significantly higher than that in the favipiravir group (31.6% vs. 6.5%; p < 0.001). Conclusions Favipiravir and hydroxychloroquine were similar in terms of improvement of clinical symptoms of healthcare workers with mild or moderate COVID-19 infection, but favipiravir was significantly more effective in reducing viral load and hospitalization rates. Furthermore, favipiravir caused significantly less side-effects than hydroxychloroquine. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
1413-8670 |
| DOI: |
10.1016/j.bjid.2022.102328 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702022000100204 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S1413.86702022000100204 |
| قاعدة البيانات: |
SciELO |
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