Academic Journal
Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
| العنوان: | Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets |
|---|---|
| المؤلفون: | Soares, Mônica Felts de La Roca, Soares Sobrinho, José Lamartine, Grangeiro Júnior, Severino, Silva, Keyla Emanuelle Ramos da, Alves, Lariza Darlene Santos, Rolim Neto, Pedro José |
| المصدر: | Química Nova. January 2010 33(2) |
| بيانات النشر: | Sociedade Brasileira de Química, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | ornidazole, quality control, dissolution test |
| الوصف: | This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph. |
| نوع الوثيقة: | article |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0100-4042 |
| DOI: | 10.1590/S0100-40422010000200042 |
| URL الوصول: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000200042 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edssci.S0100.40422010000200042 |
| قاعدة البيانات: | SciELO |
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