Patent
2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS
| العنوان: | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS |
|---|---|
| Document Number: | 20110136877 |
| تاريخ النشر: | June 9, 2011 |
| Appl. No: | 12/811823 |
| Application Filed: | January 06, 2009 |
| مستخلص: | The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I): [chemical expression included] |
| Inventors: | McGuinness, Brian F. (Plainsboro, NJ, US); Le, Thuy X. H. (Monmouth Junction, NJ, US); Duo, Jingqi (Paoli, PA, US); Ho, Koc-Kan (Salt Lake City, UT, US) |
| Assignees: | LIGAND PHARMACEUTICALS INC. (San Diego, CA, US) |
| Claim: | 1. A compound of formula I [chemical expression included] or a salt thereof wherein X is selected from the group consisting of hydrogen, halogen, cyano, (C1-C4)alkyl, —O(C1-C4)alkyl and —S(O)m(C1-C4)alkyl, each (C1-C4)alkyl optionally substituted with one chlorine, iodine or bromine atom or one or more fluorine atoms; m is zero, one or two; n is one or two; Y is carbon or SO; Q is oxygen, NH or (CH2)P, with the proviso that when Y is SO, Q cannot be oxygen; p is zero or 1-4; R4 is selected from the group consisting of: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents chosen from (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents chosen from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; and (c) (C1-C8)heteroalkyl; q is zero or 1-4; and R7 is chosen from: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents from the group consisting of (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; (c) (C1-C8)heteroalkyl; and (d) CON(H) (C1-C8)alkyl; with the proviso that when Q is (CH2)P, R4 and R7 cannot both be alkyl. |
| Claim: | 2. A compound or salt according to claim 1 wherein n is one. |
| Claim: | 3. A compound or salt according to claim 1 wherein the (CH2)n substituent is in the meta position. |
| Claim: | 4. A compound or salt according to claim 1 wherein Y is equal to carbon. |
| Claim: | 5. A compound or salt according to claim 4 wherein Q is equal to oxygen and R4 is alkyl, heteroaryl or aryl. |
| Claim: | 6. A compound or salt according to claim 5 wherein R4 is butyl. |
| Claim: | 7. A compound or salt according to claim 1 wherein q is one. |
| Claim: | 8. A compound or salt according to claim 7 wherein R7 is CON(H)alkyl. |
| Claim: | 9. A compound or salt according to claim 8 wherein R7 is CON(H)butyl. |
| Claim: | 10. A compound or salt according to claim 1 wherein q is zero and R7 is methyl. |
| Claim: | 11. A compound or salt according to claim 3 wherein X is selected from the group consisting of hydrogen, halogen, CF3 and alkyl; n is one; Y is carbon; Q is oxygen; R4 is a (C1-C4)alkyl; q is one; and R7 is chosen from: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents from the group consisting of (C1-C4)alkyl, (C1-C4)alkoxy, haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; (c) heteroalkyl; and (d) CON(H)(C1-C8)alkyl. |
| Claim: | 12. A compound or salt according to claim 11 wherein R7 is CON(H)alkyl. |
| Claim: | 13. A compound or salt according to claim 3 of formula II [chemical expression included] wherein X is selected from the group consisting of hydrogen, halogen, CF3 and alkyl. |
| Claim: | 14. A compound or salt according to claim 1 wherein Y is equal to SO. |
| Claim: | 15. A compound or salt according to claim 14 wherein Q is (CH2)P, p is zero, and R4 is an aryl or a heteroaryl. |
| Claim: | 16. A compound or salt according to claim 1 wherein the (CH2)n substituent is in the para position. |
| Claim: | 17. A compound or salt according to claim 1 wherein X is hydrogen, alkyl, CF3, chlorine or fluorine. |
| Claim: | 18. A compound or salt according to claim 17 wherein X is methyl. |
| Claim: | 19. A compound or salt according to claim 1 wherein X is CF3. |
| Claim: | 20. A compound or salt according to claim 19 wherein R7 is aryl or heteroaryl. |
| Claim: | 21. A compound or salt according to claim 1 wherein R4 is selected from phenyl and pyridine. |
| Claim: | 22. A compound or salt according to claim 1 wherein R7 is selected from phenyl and thiazole. |
| Claim: | 23. A compound or salt thereof according to claim 1 selected from {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(butylamino)-2-oxoethyl]amino}methyl)-5-fluorobiphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(butylamino)-2-oxoethyl]amino}methyl)-5-methylbiphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)-5-chlorobiphenyl-2-yl]oxy}acetic acid, {[3′-{[[2-(butylamino)-2-oxoethyl] (phenylacetyl)amino]methyl}-biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(butyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(methylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′4 {(acetyl) [2-(methylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[acetyl(phenyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(phenylcarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(phenoxycarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(phenyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(1,3-thiazol-2-ylmethyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(anilinocarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({methyl[(pyridine-2-ylamino)carbonyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butylaminocarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′4 {methyl[(pyridine-2-yloxy)carbonyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(pyridine-3-ylcarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(benzensulfonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(pyridine-3-ylsulfonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, and {[4′-({(butoxy carbonyl) [2-(butylamino)-2-oxoethyl]amino}ethyl)biphenyl-2-yl]oxy}acetic acid. |
| Claim: | 24. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound or salt according to claim 1. |
| Claim: | 25. A method of treating, preventing or ameliorating a disorder responsive to inhibition of chemoattractant receptor-homogolous molecule expressed on T helper 2 cells, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound or salt according to claim 1. |
| Claim: | 26. A method according to claim 25 wherein said disorder is an inflammatory disease. |
| Claim: | 27. A method according to claim 25 wherein said disorder is a respiratory disease. |
| Claim: | 28. A method according to claim 25 wherein said disorder is selected from asthma, rhinitis, chronic obstructive pulmonary disease, bronchitis, nasal polyposis, nasal congestion, farmer's lung, fibroid lung and cough. |
| Claim: | 29. A method according to claim 25 wherein said disorder is a skin disorder. |
| Claim: | 30. A method according to claim 25 wherein said disorder is dermatitis, cutaneous eosinophilias, Lichen planus, urticaria, psoriasis, pruritus, angiodermas, corneal ulcers, chronic skin ulcers, conjunctivitis, vasculitides, uveitis or erythemas. |
| Claim: | 31. A method according to claim 25 wherein said disorder is selected from osteoarthritis, rheumatoid arthritis, pain and inflammatory bowel disease. |
| Claim: | 32. A method according to claim 25 wherein said subject is a human. |
| Claim: | 33. A salt of a compound according to claim 1 wherein said salt is a pharmaceutically acceptable salt. |
| Claim: | 34. (canceled) |
| Claim: | 35. (canceled) |
| Claim: | 36. (canceled) |
| Claim: | 37. (canceled) |
| Claim: | 38. (canceled) |
| Claim: | 39. (canceled) |
| Claim: | 40. (canceled) |
| Claim: | 41. (canceled) |
| Claim: | 42. (canceled) |
| Claim: | 43. (canceled) |
| Claim: | 44. (canceled) |
| Claim: | 45. (canceled) |
| Claim: | 46. (canceled) |
| Claim: | 47. (canceled) |
| Current U.S. Class: | 514/346 |
| Current International Class: | 61; 07; 61; 07; 07; 61; 07; 61; 07; 07; 61; 07; 61; 61; 61; 61; 61; 61; 61; 61 |
| رقم الانضمام: | edspap.20110136877 |
| قاعدة البيانات: | USPTO Patent Applications |
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edspap USPTO Patent Applications edspap.20110136877 721 3 Patent patent 721.236755371094 |
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Array ( [Name] => DocumentID [Label] => Document Number [Group] => Patent [Data] => 20110136877 ) Array ( [Name] => DateEntry [Label] => Publication Date [Group] => Patent [Data] => June 9, 2011 ) Array ( [Name] => DocumentID [Label] => Appl. No [Group] => Patent [Data] => 12/811823 ) Array ( [Name] => DateFiled [Label] => Application Filed [Group] => Patent [Data] => January 06, 2009 ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I): [chemical expression included] ) Array ( [Name] => Author [Label] => Inventors [Group] => Patent [Data] => <searchLink fieldCode="ZA" term="%22McGuinness%2C+Brian+F%2E%22">McGuinness, Brian F.</searchLink> (Plainsboro, NJ, US); <searchLink fieldCode="ZA" term="%22Le%2C+Thuy+X%2E+H%2E%22">Le, Thuy X. H.</searchLink> (Monmouth Junction, NJ, US); <searchLink fieldCode="ZA" term="%22Duo%2C+Jingqi%22">Duo, Jingqi</searchLink> (Paoli, PA, US); <searchLink fieldCode="ZA" term="%22Ho%2C+Koc-Kan%22">Ho, Koc-Kan</searchLink> (Salt Lake City, UT, US) ) Array ( [Name] => OtherAuthors [Label] => Assignees [Group] => Patent [Data] => <searchLink fieldCode="ZS" term="%22LIGAND+PHARMACEUTICALS+INC%2E%22">LIGAND PHARMACEUTICALS INC.</searchLink> (San Diego, CA, US) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 1. A compound of formula I [chemical expression included] or a salt thereof wherein X is selected from the group consisting of hydrogen, halogen, cyano, (C1-C4)alkyl, —O(C1-C4)alkyl and —S(O)m(C1-C4)alkyl, each (C1-C4)alkyl optionally substituted with one chlorine, iodine or bromine atom or one or more fluorine atoms; m is zero, one or two; n is one or two; Y is carbon or SO; Q is oxygen, NH or (CH2)P, with the proviso that when Y is SO, Q cannot be oxygen; p is zero or 1-4; R4 is selected from the group consisting of: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents chosen from (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents chosen from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; and (c) (C1-C8)heteroalkyl; q is zero or 1-4; and R7 is chosen from: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents from the group consisting of (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; (c) (C1-C8)heteroalkyl; and (d) CON(H) (C1-C8)alkyl; with the proviso that when Q is (CH2)P, R4 and R7 cannot both be alkyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 2. A compound or salt according to claim 1 wherein n is one. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 3. A compound or salt according to claim 1 wherein the (CH2)n substituent is in the meta position. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 4. A compound or salt according to claim 1 wherein Y is equal to carbon. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 5. A compound or salt according to claim 4 wherein Q is equal to oxygen and R4 is alkyl, heteroaryl or aryl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 6. A compound or salt according to claim 5 wherein R4 is butyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 7. A compound or salt according to claim 1 wherein q is one. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 8. A compound or salt according to claim 7 wherein R7 is CON(H)alkyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 9. A compound or salt according to claim 8 wherein R7 is CON(H)butyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 10. A compound or salt according to claim 1 wherein q is zero and R7 is methyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 11. A compound or salt according to claim 3 wherein X is selected from the group consisting of hydrogen, halogen, CF3 and alkyl; n is one; Y is carbon; Q is oxygen; R4 is a (C1-C4)alkyl; q is one; and R7 is chosen from: (a) aryl and heterocyclyl, each optionally substituted with one to three substituents from the group consisting of (C1-C4)alkyl, (C1-C4)alkoxy, haloalkyl, halogen, cyano and (C1-C4)haloalkoxy; (b) (C1-C8)alkyl, optionally substituted with one to three substituents from the group consisting of (C1-C8)alkyl, (C1-C8)haloalkyl, chlorine, iodine, bromine, cyano and (C1-C8)haloalkoxy or optionally substituted with one or more fluorine atoms; (c) heteroalkyl; and (d) CON(H)(C1-C8)alkyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 12. A compound or salt according to claim 11 wherein R7 is CON(H)alkyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 13. A compound or salt according to claim 3 of formula II [chemical expression included] wherein X is selected from the group consisting of hydrogen, halogen, CF3 and alkyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 14. A compound or salt according to claim 1 wherein Y is equal to SO. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 15. A compound or salt according to claim 14 wherein Q is (CH2)P, p is zero, and R4 is an aryl or a heteroaryl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 16. A compound or salt according to claim 1 wherein the (CH2)n substituent is in the para position. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 17. A compound or salt according to claim 1 wherein X is hydrogen, alkyl, CF3, chlorine or fluorine. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 18. A compound or salt according to claim 17 wherein X is methyl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 19. A compound or salt according to claim 1 wherein X is CF3. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 20. A compound or salt according to claim 19 wherein R7 is aryl or heteroaryl. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 21. A compound or salt according to claim 1 wherein R4 is selected from phenyl and pyridine. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 22. A compound or salt according to claim 1 wherein R7 is selected from phenyl and thiazole. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 23. A compound or salt thereof according to claim 1 selected from {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(butylamino)-2-oxoethyl]amino}methyl)-5-fluorobiphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(butylamino)-2-oxoethyl]amino}methyl)-5-methylbiphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl) [2-(butylamino)-2-oxoethyl]amino}methyl)-5-chlorobiphenyl-2-yl]oxy}acetic acid, {[3′-{[[2-(butylamino)-2-oxoethyl] (phenylacetyl)amino]methyl}-biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(butyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({(butoxycarbonyl)[2-(methylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′4 {(acetyl) [2-(methylamino)-2-oxoethyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[acetyl(phenyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(phenylcarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(phenoxycarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(phenyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butoxycarbonyl)(1,3-thiazol-2-ylmethyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(anilinocarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-({methyl[(pyridine-2-ylamino)carbonyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(butylaminocarbonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′4 {methyl[(pyridine-2-yloxy)carbonyl]amino}methyl)-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[methyl(pyridine-3-ylcarbonyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(benzensulfonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, {[3′-{[(pyridine-3-ylsulfonyl)(methyl)amino]methyl}-5-(trifluoromethyl)biphenyl-2-yl]oxy}acetic acid, and {[4′-({(butoxy carbonyl) [2-(butylamino)-2-oxoethyl]amino}ethyl)biphenyl-2-yl]oxy}acetic acid. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 24. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound or salt according to claim 1. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 25. A method of treating, preventing or ameliorating a disorder responsive to inhibition of chemoattractant receptor-homogolous molecule expressed on T helper 2 cells, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound or salt according to claim 1. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 26. A method according to claim 25 wherein said disorder is an inflammatory disease. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 27. A method according to claim 25 wherein said disorder is a respiratory disease. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 28. A method according to claim 25 wherein said disorder is selected from asthma, rhinitis, chronic obstructive pulmonary disease, bronchitis, nasal polyposis, nasal congestion, farmer's lung, fibroid lung and cough. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 29. A method according to claim 25 wherein said disorder is a skin disorder. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 30. A method according to claim 25 wherein said disorder is dermatitis, cutaneous eosinophilias, Lichen planus, urticaria, psoriasis, pruritus, angiodermas, corneal ulcers, chronic skin ulcers, conjunctivitis, vasculitides, uveitis or erythemas. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 31. A method according to claim 25 wherein said disorder is selected from osteoarthritis, rheumatoid arthritis, pain and inflammatory bowel disease. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 32. A method according to claim 25 wherein said subject is a human. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 33. A salt of a compound according to claim 1 wherein said salt is a pharmaceutically acceptable salt. ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 34. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 35. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 36. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 37. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 38. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 39. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 40. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 41. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 42. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 43. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 44. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 45. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 46. (canceled) ) Array ( [Name] => Comment [Label] => Claim [Group] => Patent [Data] => 47. (canceled) ) Array ( [Name] => CodeClass [Label] => Current U.S. Class [Group] => Patent [Data] => 514/346 ) Array ( [Name] => CodeClass [Label] => Current International Class [Group] => Patent [Data] => 61; 07; 61; 07; 07; 61; 07; 61; 07; 07; 61; 07; 61; 61; 61; 61; 61; 61; 61; 61 ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edspap.20110136877 ) |
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[M] => 06
[Text] => June 9, 2011
[Type] => published
[Y] => 2011
)
)
)
)
)
)
)
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| IllustrationInfo |