Electronic Resource
Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
| العنوان: | Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata |
|---|---|
| المؤلفون: | Química analítica, Zoología y biología celular animal, Kimika analitikoa, Zoologia eta animalia zelulen biologia, Blanco Rayón, Esther, Ziarrusta Intxaurtza, Haizea, Mijangos Treviño, Leire, Olivares Zabalandicoechea, Maitane, Zuloaga Zubieta, Olatz, Etxebarria Loizate, Nestor, Izaguirre Aramayona, Urtzi |
| بيانات النشر: | Elsevier 2021-11 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | [EN]Amitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment and therefore they are released to rivers, estuaries and coastal waters. The presence of this kind of compounds in the water environment may involve a negative impact on non-target aquatic organisms at relatively low concentrations. However, the knowledge of AMI effects on aquatic organisms in the environment is scarce. Thus, the objective of this work is to determine the effects of environmentally-relevant concentrations of AMI on biological responses at biochemical and cellular levels in marine teleost. Gilt-head seabream (S. aurata) were exposed to AMI for 7 days at 0.2 mu g/L in an open flow system and a battery of biomarkers were investigated: acetylcholinesterase, catalase, superoxide dismutase, glutathione S-transferase, cytochrome C oxidase, P450 CYP1A1 ethoxyresorufin (O) dealkylation, and lysosomal biomarkers. Biomarkers were integrated as IBR/n (biological response index). Overall, it can be concluded that AMI exposure at environmentally-relevant concentration induces significant biological responses to stress in marine teleost, especially in lysosomal biomarkers. However, further research is needed about the effects of AMI and other pharmaceuticals on biomarkers in nontargeted species, to raise the knowledge about the toxicity of this type of emerging pollutants. |
| مصطلحات الفهرس: | gilt-head seabream, biomarkers, lysosomes, AMI, info:eu-repo/semantics/article |
| URL: | 1470-160X 1872-7034 info:eu-repo/grantAgreement/MINECO/CTM2017-84763-C3-1-R |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | The authors are indebted to Ainhoa Camille for helping us with her invaluable technical support. This work was financially supported by the Ministry of Economy and Competitiveness through the project CTM2017-84763-C3-1-R and the Basque Government (IT-742-13 & IT1213-19). H. Ziarrusta is grateful to the Spanish Ministry predoctoral fellowship and L. Mijangos to the University of the Basque Country for her postdoctoral fellowship. English |
| Other Numbers: | ESUPV oai:addi.ehu.es:10810/54236 1288148804 |
| المصدر المساهم: | REPOSITORIO DE LA UNIVERSIDAD DEL PAIS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1288148804 |
| قاعدة البيانات: | OAIster |
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