Dissertation/ Thesis
Synthesis of Mesoporous Silica Nanoparticle Encapsulated Alginate Microparticles for Sustained Release and Targeting Chemotherapy
| العنوان: | Synthesis of Mesoporous Silica Nanoparticle Encapsulated Alginate Microparticles for Sustained Release and Targeting Chemotherapy |
|---|---|
| Alternate Title: | 合成包覆中孔洞氧化矽奈米顆粒之海藻酸微米顆粒應用於穩定釋放以及標靶化學治療 |
| المؤلفون: | Yu-Te Liao, 廖祐德 |
| Thesis Advisors: | Chia-Wen Wu, 吳嘉文 |
| سنة النشر: | 2012 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 100 This study reports the synthesis of mesoporous silica nanoparticles encapsulated alginate microparticles (MSN@Alg) for sustained release and targeting chemotherapy. The MSN@Alg was synthesized by air dynamical atomization, and the effects of several critical factors including concentration of alginate solution, flow rate of alginate solution, flow rate of air, the distance between nozzle and calcium bath, and stirring rate of calcium on the particle size of the synthesized MSN@Alg were investigated. For example, an uniformly distributed, spherical MSN@Alg with 20 um in diameter could be successfully produced when the reaction conditions were chosen as follows: the concentration of alginate solution was 1%, the flow rate of alginate solution was 0.5 mL/min, the flow rate of air was 500 mbar/cm2, the length between nozzle and calcium bath was 6 cm, and the rate of stirring of calcium bath was 300 r.p.m. with 0.3% MSN. For studying the sustained release properties of the MSN@Alg, rhodamine 6G (R6G) was used as a model drug, and we compared the release properties of R6G/MSN and R6G/MSN@Alg by using different concentrations of alginate, concentrations and volumes of PBS buffer solutions. The sustained release behavior of the R6G/MSN@Alg system can be prolonged to 20 days with an optimal condition of 1 mg R6G/MSN@Alg to 2 mL PBS (10 mM). For specific targeting chemotherapy, an anti-cancer drug, doxorubicin (Dox), was used to loaded into MSN@Alg, and a RGD-based peptide was functionalized onto the surface of MSN@Alg for the purpose of specific targeting. The results showed that the intracellular drug delivery efficiency was greatly enhanced (i.e, 3.5 folds) for the Dox/MSN@Alg/RGD drug delivery system. |
| Original Identifier: | 100NTU05063068 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 94 |
| الاتاحة: | http://ndltd.ncl.edu.tw/handle/04792611690497745639 |
| رقم الانضمام: | edsndl.TW.100NTU05063068 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
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