التفاصيل البيبلوغرافية
| العنوان: |
Genetic strategies for sex-biased persistence of gut microbes across human life |
| المؤلفون: |
Chiara Tarracchini, Giulia Alessandri, Federico Fontana, Sonia Mirjam Rizzo, Gabriele Andrea Lugli, Massimiliano Giovanni Bianchi, Leonardo Mancabelli, Giulia Longhi, Chiara Argentini, Laura Maria Vergna, Rosaria Anzalone, Alice Viappiani, Francesca Turroni, Giuseppe Taurino, Martina Chiu, Silvia Arboleya, Miguel Gueimonde, Ovidio Bussolati, Douwe van Sinderen, Christian Milani, Marco Ventura |
| المصدر: |
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023) |
| بيانات النشر: |
Nature Portfolio, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Abstract Although compositional variation in the gut microbiome during human development has been extensively investigated, strain-resolved dynamic changes remain to be fully uncovered. In the current study, shotgun metagenomic sequencing data of 12,415 fecal microbiomes from healthy individuals are employed for strain-level tracking of gut microbiota members to elucidate its evolving biodiversity across the human life span. This detailed longitudinal meta-analysis reveals host sex-related persistence of strains belonging to common, maternally-inherited species, such as Bifidobacterium bifidum and Bifidobacterium longum subsp. longum. Comparative genome analyses, coupled with experiments including intimate interaction between microbes and human intestinal cells, show that specific bacterial glycosyl hydrolases related to host-glycan metabolism may contribute to more efficient colonization in females compared to males. These findings point to an intriguing ancient sex-specific host-microbe coevolution driving the selective persistence in women of key microbial taxa that may be vertically passed on to the next generation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-023-39931-2 |
| URL الوصول: |
https://doaj.org/article/f93d63a7937e4ac898153b02956bdc7a |
| رقم الانضمام: |
edsdoj.f93d63a7937e4ac898153b02956bdc7a |
| قاعدة البيانات: |
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