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Baseline high-sensitivity C-reactive protein and glycosylated hemoglobinA1c predict adverse outcomes in patients with chronic coronary syndromes undergoing percutaneous coronary intervention

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العنوان: Baseline high-sensitivity C-reactive protein and glycosylated hemoglobinA1c predict adverse outcomes in patients with chronic coronary syndromes undergoing percutaneous coronary intervention
المؤلفون: Xiao-Fang Tang, De-Shan Yuan, Pei Zhu, Na Xu, Yi Yao, Pei-Zhi Wang, Yan Chen, Li-Jian Gao, Lei Song, Yue-Jin Yang, Run-Lin Gao, Xue-Yan Zhao, Jin-Qing Yuan
المصدر: Heliyon, Vol 10, Iss 1, Pp e23900- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: High-sensitivity C-Reactive protein, Glycosylated hemoglobinA1c, Chronic coronary syndromes, Percutaneous coronary intervention, Prognosis, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Introduction: This study explored the ability of high-sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin A1c (HbA1c) to predict adverse cardiac and cerebrovascular outcomes in patients with chronic coronary syndromes (CCS) undergoing percutaneous coronary intervention (PCI). Methods: In total, 4083 consecutive patients with CCS undergoing PCI were investigated throughout 2013 at a single center. The primary endpoint was all-cause death at the 5-year follow-up. Hs-CRP and HbA1c data were collected on admission. Results: The highest quartile of hs-CRP had a significantly increased the risk of all-cause death, with an adjusted HR of 1.747 (95 % CI 1.066–2.863), while, there was no difference in all-cause death among the groups of HbA1c after adjustment, with an adjusted HR of 1.383 (95 % CI 0.716–2.674). The highest quartiles for hs-CRP and HbA1c in the study population had a significantly increased risk of major adverse cardiac and cerebrovascular events (MACCE), with an adjusted hazard ratios (HR) of 1.263 (95 % confidence intervals [CI] 1.032–1.545) for hs-CRP and an adjusted HR of 1.417 (95 % CI 1.091–1.840) for HbA1c. Remarkably, the incidence of all-cause death and that of MACCE were significantly increased when both hs-CRP and HbA1c were elevated (HR 1.971, 95 % CI 1.079–3.601, P = 0.027 and HR 1.560, 95 % CI 1.191–2.042), P = 0.001, respectively). Addition of hs-CRP and HbA1c to conventional risk factors significantly improved prediction of the risk of all cause death (net reclassification index 0.492, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S240584402311108X; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2023.e23900
URL الوصول: https://doaj.org/article/f8fb1a377405443ebc351b56505ce061
رقم الانضمام: edsdoj.f8fb1a377405443ebc351b56505ce061
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2023.e23900