Academic Journal
Therapeutic Efficacy of Excretory-Secretory Products of Trichinella spiralis Adult Worms on Sepsis-Induced Acute Lung Injury in a Mouse Model
| العنوان: | Therapeutic Efficacy of Excretory-Secretory Products of Trichinella spiralis Adult Worms on Sepsis-Induced Acute Lung Injury in a Mouse Model |
|---|---|
| المؤلفون: | Huihui Li, Dapeng Qiu, Huijuan Yang, Yuan Yuan, Lingqin Wu, Liang Chu, Bin Zhan, Xiaoli Wang, Yan Sun, Wei Xu, Xiaodi Yang |
| المصدر: | Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | excretory-secretory products, Trichinella spiralis, sepsis, acute lung injury, cecal ligation and puncture, immunomodulation, Microbiology, QR1-502 |
| الوصف: | Acute lung injury (ALI) is a common complication of systemic inflammation or sepsis with high morbidity and mortality. Although many studies have confirmed that helminth-derived proteins had strong immunomodulatory functions and could be used to treat inflammatory diseases, there is no report on the therapeutic effect of excretory-secretory products of Trichinella spiralis adult worms (Ts-AES) on sepsis-induced ALI. In this study, the therapeutic efficacy of Ts-AES on sepsis-induced ALI and the underlying immunological mechanism and the signaling pathway were investigated. The results indicated that after being treated with Ts-AES, the survival rate of mice with CLP-induced sepsis was significantly increased to 50% for 72 hours after CLP surgery compared to PBS control group with all mice died. The sepsis-induced ALI was largely mitigated characterized by reduced inflammation cell infiltration and pathological changes in lung tissue, with decreased lung injury scores and lung wet/dry weight ratio. The therapeutic efficacy of Ts-AES is associated with stimulated Tregs response with increased regulatory cytokines IL-10 and TGF-β and downregulated pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). The expression of HMGB1, TLR2 and MyD88 in lung tissue was inhibited after treatment of Ts-AES. Our results demonstrated that Ts-AES play an important role in immunomodulation and confer a therapeutic effect on sepsis-induced ALI through inhibiting pro-inflammatory cytokines. The activation of Tregs and increased level of regulatory cytokines IL-10 and TGF-β are possibly involved in the immunomodulatory functions of Ts-AES through HMGB1/TLR2/MyD88 signal pathway. The findings suggest Ts-AES is a potential therapeutic agent for prevention and treatment of sepsis-induced ALI and other inflammatory diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2235-2988 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.653843/full; https://doaj.org/toc/2235-2988 |
| DOI: | 10.3389/fcimb.2021.653843 |
| URL الوصول: | https://doaj.org/article/af4c4a44337d42e49e02469cc51a39e4 |
| رقم الانضمام: | edsdoj.f4c4a44337d42e49e02469cc51a39e4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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