التفاصيل البيبلوغرافية
| العنوان: |
Protocol of quantitative ultrasound techniques for noninvasive assessing of hepatic steatosis after bariatric surgery |
| المؤلفون: |
Bin Chen, Qijie Lu, Bing Hu, Di Sun, Tao Ying |
| المصدر: |
Frontiers in Surgery, Vol 10 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Surgery |
| مصطلحات موضوعية: |
quantitative ultrasound, tissue attenuation imaging, tissue scatter distribution imaging, metabolism-associated fatty liver disease, obesity, Roux-en-Y gastric bypass, Surgery, RD1-811 |
| الوصف: |
IntroductionRoux-en-Y gastric bypass surgery can effectively improve steatosis, necroinflammatory activity, and hepatic fibrosis in individuals diagnosed with morbid obesity or nonalcoholic steatohepatitis (NASH). Common methods such as body mass index (BMI) to evaluate the postoperative effect of clinical bariatric surgery cannot differentiate subcutaneous fats from visceral fats and muscles. Several Quantitative ultrasound (QUS)–based approaches have been developed to quantify hepatic steatosis. QUS techniques (tissue attenuation imaging (TAI), tissue scatter distribution imaging (TSI)) from radio frequency (RF) data analysis as a means for the detection and grading of hepatic steatosis has been posited as an objective and noninvasive approach. The implementation and standardization of QUS techniques (TAI, TSI) in assessing hepatic steatosis quantitatively after bariatric surgery is of high-priority. Our study is aimed to assess hepatic steatosis with QUS techniques (TAI, TSI) in morbidly obese individuals before and after bariatric surgery, and to compare with anthropometric measurements, laboratory assessments and other imaging methods.Methods and analysisThe present investigation, a self-discipline examination of navigational capacity devoid of visual cues, is designed as a single-site, forward-looking evaluation of efficacy with the imprimatur of the institutional review board. The duration of the study has been provisionally determined to span from 1 January 2023 through 31 December 2025. Our cohort shall encompass one hundred participants, who was scheduled to undergo Roux-en-Y gastric bypass (RYGB) at Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. All patients will undergo anthropometric measurements, blood-based biochemical analyses, ultrasonic examination and magnetic resonance imaging proton density fat fraction (MRI-PDFF). The primary endpoint is the analysis of evaluating the efficacy of QUS techniques assessing hepatic steatosis compared to other methods before and after bariatric surgery.ResultsPrior to the fomal study, we recruited 21 obese Chinese participants who received ultrasonic examination (TAI, TSI) and MRI-PDFF. AC-TAI showed moderate correlations with MRI-PDFF (adjusted r = 0.632; P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-875X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fsurg.2023.1244199/full; https://doaj.org/toc/2296-875X |
| DOI: |
10.3389/fsurg.2023.1244199 |
| URL الوصول: |
https://doaj.org/article/f20f449bb1264a75a0ee5244855ee203 |
| رقم الانضمام: |
edsdoj.f20f449bb1264a75a0ee5244855ee203 |
| قاعدة البيانات: |
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