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Fixed Ratio versus Lower Limit of Normality for Diagnosing COPD in Primary Care: Long-Term Follow-Up of EGARPOC Study

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العنوان: Fixed Ratio versus Lower Limit of Normality for Diagnosing COPD in Primary Care: Long-Term Follow-Up of EGARPOC Study
المؤلفون: Llordés M, Jaen A, Zurdo E, Roca M, Vazquez I, Almagro P
المصدر: International Journal of COPD, Vol Volume 15, Pp 1403-1413 (2020)
بيانات النشر: Dove Medical Press, 2020.
سنة النشر: 2020
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: copd, lower limit of normality, fixed ratio, prognosis, airway obstruction, mortality., Diseases of the respiratory system, RC705-779
الوصف: Montserrat Llordés,1 Angeles Jaen,2 Elba Zurdo,1 Montserrat Roca,1 Inmaculada Vazquez,1 Pere Almagro3 On behalf of the EGARPOC collaboration group1Terrassa Sud Primary Care Center, Hospital Universitari Mutua Terrassa, University of Barcelona, Barcelona, Spain; 2Fundació Docència i Recerca Mutua Terrassa, Barcelona, Spain; 3Internal Medicine Service, Hospital Universitari Mutua Terrassa, University of Barcelona, Barcelona, SpainCorrespondence: Montserrat LlordésTerrassa Sud Primary Care Center, Hospital Universitari Mutua Terrassa, Avenida Santa Eulalia s/n, Terrassa, Barcelona 08223, SpainTel +34 93 785 51 61Fax +34 93 731 49 52Email mllordes@mutuaterrassa.catPurpose: The best criterion for diagnosing airway obstruction in COPD, fixed ratio (FR: FEV1/FVC< 0.7) or lower limit of normality (LLN), remains controversial. We compared the long-term evolution of COPD patients according to the initial obstruction criteria.Patients and Methods: Between 2005 and 2008, we evaluated 1728 subjects over 45 years of age with smoking history, pertaining to a primary care center. A total of 424 patients were obstructive by FR, after a bronchodilator test. Of those, 289 patients met obstruction criteria for both FR and LLN and were considered concordant patients (FR+LLN+), while 135 patients were obstructive by FR but non-obstructive by LLN and were defined as discordant patients (FR+LLN-).Results: Forty-eight patients (11.3%) were lost in follow-up, and 158 died (37.3%). After a median time of 120.4 months (IQR 25– 75%: 110.2– 128.8), 215 patients were spirometrically reevaluated. The annualized loss of FEV1/FVC was greater in discordant (FR+LLN-) patients [0.54 (0.8) vs 0.82 (0.7); p = 0.008], while 81% became concordant (FR+LLN+) during the follow-up. Hospitalization for COPD exacerbations was more frequent in concordant (FR+LLN+) patients (1.57± 3.51 vs 0.77± 2.29; p = 0.002). Adjusting for age, concordant (FR+LLN+) patients had greater COPD mortality (HR: 2.97; CI 95%: 1.27– 7.3; p = 0.02).Conclusion: LLN seems to be less useful for COPD diagnosis in primary care. Discordant (FR+LLN-) patients lost more FEV1/FVC during their evolution and tended to become concordant. LLN predicted COPD hospitalizations and mortality more poorly.Keywords: COPD, lower limit of normality, fixed ratio, prognosis, airway obstruction, mortality
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-2005
Relation: https://www.dovepress.com/fixed-ratio-versus-lower-limit-of-normality-for-diagnosing-copd-in-pri-peer-reviewed-article-COPD; https://doaj.org/toc/1178-2005
URL الوصول: https://doaj.org/article/cf19ab2d483947a9b4bd764d0315b326
رقم الانضمام: edsdoj.f19ab2d483947a9b4bd764d0315b326
قاعدة البيانات: Directory of Open Access Journals
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