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In vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis

التفاصيل البيبلوغرافية
العنوان: In vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
المؤلفون: Ali Reza Khosravi, Hojjatollah Shokri, Shahin Eshghi
المصدر: Iranian Journal of Basic Medical Sciences, Vol 20, Iss 2, Pp 193-198 (2017)
بيانات النشر: Mashhad University of Medical Sciences, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
مصطلحات موضوعية: Candida albicans, Cytokine production, Lymphocyte proliferation, Mitogens, Mice, Systemic candidiasis, Medicine
الوصف: Objective(s): Systemic candidiasis is an infection of Candida albicans (C. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. We investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with Concanavalin A (Con A) and Pokeweed mitogen (PWM) in mice with disseminated candidiasis. Materials and Methods:Lymphoproliferative responses were stimulated in vitro with Con A (1 µg/ml) and PWM (1 µg/ml) mitogens in Roswell Park Memorial Institute (RPMI) 1640 media, and the production of interferon (IFN)-γ and interleukin-4 (IL-4) in the supernatants was measured by enzyme-linked immunosorbent assay (ELISA). Results: The results revealed that C. albicans organisms multiplied to a greater extent in the kidneys than in the liver and spleen of infected mice. The most predominant forms of C. albicans in different parts of the kidneys were yeast mixed with hyphal forms. Infected mice had a significantly increased proliferative response when splenocytes were stimulated with PWM (2.0±0.16) and Con A (1.9±0.19) (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2008-3866
2008-3874
Relation: http://ijbms.mums.ac.ir/article_8248_bc3978618ad156c11d070f423090e845.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874
DOI: 10.22038/ijbms.2017.8248
URL الوصول: https://doaj.org/article/b26975f1392049c7a3fe644871896737
رقم الانضمام: edsdoj.b26975f1392049c7a3fe644871896737
قاعدة البيانات: Directory of Open Access Journals
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