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Transcriptomic analysis reveals the lipid metabolism-related gene regulatory characteristics and potential therapeutic agents for myocardial ischemia-reperfusion injury

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العنوان: Transcriptomic analysis reveals the lipid metabolism-related gene regulatory characteristics and potential therapeutic agents for myocardial ischemia-reperfusion injury
المؤلفون: Jiahe Wu, Huanhuan Cai, Xiaorong Hu, Wei Wu
المصدر: Frontiers in Cardiovascular Medicine, Vol 11 (2024)
بيانات النشر: Frontiers Media S.A., 2024.
سنة النشر: 2024
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: myocardial ischemia-reperfusion injury, lipid metabolism, lipid metabolism-related genes, therapeutic agent, bioinformatics analysis, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: BackgroundImpaired energy balance caused by lipid metabolism dysregulation is an essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to explore the lipid metabolism-related gene (LMRG) expression patterns in MI/RI and to find potential therapeutic agents.MethodsDifferential expression analysis was performed to screen the differentially expressed genes (DEGs) and LMRGs in the MI/RI-related dataset GSE61592. Enrichment and protein-protein interaction (PPI) analyses were performed to identify the key signaling pathways and genes. The expression trends of key LMRGs were validated by external datasets GSE160516 and GSE4105. The corresponding online databases predicted miRNAs, transcription factors (TFs), and potential therapeutic agents targeting key LMRGs. Finally, the identified LMRGs were confirmed in the H9C2 cell hypoxia-reoxygenation (H/R) model and the mouse MI/RI model.ResultsEnrichment analysis suggested that the “lipid metabolic process” was one of the critical pathways in MI/RI. Further differential expression analysis and PPI analysis identified 120 differentially expressed LMRGs and 15 key LMRGs. 126 miRNAs, 55 TFs, and 51 therapeutic agents were identified targeting these key LMRGs. Lastly, the expression trends of Acadm, Acadvl, and Suclg1 were confirmed by the external datasets, the H/R model and the MI/RI model.ConclusionAcadm, Acadvl, and Suclg1 may be the key genes involved in the MI/RI-related lipid metabolism dysregulation; and acting upon these factors may serve as a potential therapeutic strategy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2297-055X
58231420
Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1281429/full; https://doaj.org/toc/2297-055X
DOI: 10.3389/fcvm.2024.1281429
URL الوصول: https://doaj.org/article/eb16d06beafa41c58231420b2a1a4612
رقم الانضمام: edsdoj.b16d06beafa41c58231420b2a1a4612
قاعدة البيانات: Directory of Open Access Journals
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