Academic Journal
North–south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic
| العنوان: | North–south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic |
|---|---|
| المؤلفون: | Isaac Miguel, Edwin P. Feliz, Robinson Agramonte, Pedro V. Martinez, Carlos Vergara, Yvonne Imbert, Lucia De la Cruz, Nurys de Castro, Odalis Cedano, Yamilka De la Paz, Vagner Fonseca, Gilberto A. Santiago, Jorge L. Muñoz-Jordán, Armando Peguero, Robert Paulino-Ramírez, Nathan D. Grubaugh, Ana Maria Bispo de Filippis, Luiz Carlos Junior Alcantara, Jairo Mendez Rico, José Lourenço, Leticia Franco, Marta Giovanetti |
| المصدر: | BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-8 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Dengue virus, Genomic epidemiology, Dominican Republic, Caribbean, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background Dengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus's transmission pathways and the impact of climatic factors remains limited. This study aims to elucidate the recent transmission dynamics of the dengue virus (DENV) in the Dominican Republic, utilizing a combination of genomic sequencing and epidemiological data analysis, alongside an examination of historical climate patterns. Methods We conducted a comprehensive study involving the genomic sequencing of DENV samples collected from patients across different regions of the Dominican Republic over a two-year period. Phylogenetic analyses were performed to identify the circulation of DENV lineages and to trace transmission pathways. Epidemiological data were integrated to analyze trends in dengue incidence and distribution. Additionally, we integrated historical climate data spanning several decades to assess trends in temperature and their potential impact on DENV transmission potential. Results Our results highlight a previously unknown north–south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. Conclusion This multidisciplinary study reveals intricate patterns of dengue virus transmission in the Dominican Republic, characterized by the co-circulation of multiple DENV lineages and a novel transmission pathway. The observed correlation between rising temperatures and increased dengue transmission potential emphasizes the need for integrated climate-informed strategies in dengue control efforts. Our findings offer critical insights for public health authorities in the Dominican Republic and similar settings, guiding resource allocation and the development of preparedness strategies to mitigate the impacts of climate change on dengue transmission. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2334 |
| Relation: | https://doaj.org/toc/1471-2334 |
| DOI: | 10.1186/s12879-024-09658-6 |
| URL الوصول: | https://doaj.org/article/9179947bf66949cbb0d2dddbefc10b30 |
| رقم الانضمام: | edsdoj.9179947bf66949cbb0d2dddbefc10b30 |
| قاعدة البيانات: | Directory of Open Access Journals |
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