Academic Journal
Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media
| العنوان: | Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media |
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| المؤلفون: | Argyro Bizaki-Vallaskangas, Joel Rämö, Eeva Sliz, Ilkka Kivekäs, Tytti Willberg, Elmo Saarentaus, Sanna Toppila-Salmi, Aarno Dietz, Teppo Haapaniemi, Vesa P. Hytönen, Sari Toivola, Aarno Palotie, Antti Mäkitie, Johannes Kettunen |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Finngen, Otitis media, Genome-wide association, Annexin, GAS2L2, Eustachian tube, Medicine, Science |
| الوصف: | Abstract To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative OM (7034 cases) (included serous and mucous chronic OM), mucous chronic OM (5953 cases), and secretory chronic OM (1689 cases). Individuals without otitis media were used as controls (417,745 controls). We used immunohistochemistry (IHC) of the murine middle ear to evaluate the expression of annexin A13. Four loci were significantly associated (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-68781-1 |
| URL الوصول: | https://doaj.org/article/c900bb12cbae45809bc6e06bc2152968 |
| رقم الانضمام: | edsdoj.900bb12cbae45809bc6e06bc2152968 |
| قاعدة البيانات: | Directory of Open Access Journals |
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