Academic Journal
Correlation analysis of NT-proBNP (N-terminal probrain natriuretic peptide), 25-Hydroxyvitamin D, HMGB1(High-mobility group box 1), ACTA (endogenous activin A), blood glucose level, and electrolyte level with developmental quotient scores in neonates with hypoxic-ischemic encephalopathy
| العنوان: | Correlation analysis of NT-proBNP (N-terminal probrain natriuretic peptide), 25-Hydroxyvitamin D, HMGB1(High-mobility group box 1), ACTA (endogenous activin A), blood glucose level, and electrolyte level with developmental quotient scores in neonates with hypoxic-ischemic encephalopathy |
|---|---|
| المؤلفون: | Guiling Liu, Sisi Cheng, Li Wan, Yanyan Li, Qian Zhao, Jianxin Liu, Xiufang Jiang |
| المصدر: | BMC Pediatrics, Vol 22, Iss 1, Pp 1-9 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | N-terminal probrain natriuretic peptide, 25-hydroxyvitamin D, High-mobility group box 1, Endogenous activin A, Blood glucose level, Hypoxic-ischemic encephalopathy, Pediatrics, RJ1-570 |
| الوصف: | Abstract Background To investigate the correlation between N-terminal probrain natriuretic peptide (NT-proBNP), 25-hydroxyvitamin D (25-(OH) D), high-mobility group box 1(HMGB1), endogenous activin A (ACTA), blood glucose level, electrolyte levels and developmental quotient (DQ) scores of Hypoxic-ischemic encephalopathy (HIE). Methods In this retrospective study, a total of 90 neonates diagnosed with HIE who were admitted to our hospital from January 2018 to June 2021 were retrospectively enrolled, and 40 healthy full-term neonates born in our hospital during the same period were randomly selected. Neonates with HIE and healthy conditions were set as the study group and control group, respectively. Neonates with HIE are divided into three subgroups, mild, moderate, and severe, based on the severity of HIE. The Gesell Developmental Scale (GDS) was used to assess neural development of neonates at 9 to 12 months postnatal. Biomarkers of peripheral venous blood were measured and collected in all neonates, including NT-proBNP, (25-(OH) D), HMGB1, ACTA, electrolyte levels and blood glucose levels. General demographic information and Apgar score were compared between the two groups. The differences between the two groups of biomarkers were compared and the correlation between these biomarkers and DQ scores was evaluated. Results There was no significant difference in gestational age, maternal age, gender, way of birth, birth weight, gestational age and whether the mother was a primipara between the two groups (P>0.05). The 10 min Apgar score of the study group (5.87±0.36) was lower than that of the control group (9.37±0.32) with significant difference (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2431 |
| Relation: | https://doaj.org/toc/1471-2431 |
| DOI: | 10.1186/s12887-022-03606-6 |
| URL الوصول: | https://doaj.org/article/8c806452aa7a47208076fa26a60bc709 |
| رقم الانضمام: | edsdoj.8c806452aa7a47208076fa26a60bc709 |
| قاعدة البيانات: | Directory of Open Access Journals |
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