Academic Journal
Development and validation of a novel prognostic prediction system based on GLIM-defined malnutrition for colorectal cancer patients post-radical surgery
| العنوان: | Development and validation of a novel prognostic prediction system based on GLIM-defined malnutrition for colorectal cancer patients post-radical surgery |
|---|---|
| المؤلفون: | Xialin Yan, Junchang Zhu, Junqi Wang, Yingjie Lu, Xingzhao Ye, Xiangwei Sun, Haojie Jiang, Zongze Li, Chenhao He, Wenbo Zhai, Qiantong Dong, Weizhe Chen, Zhen Yu, Yifei Pan, Dongdong Huang |
| المصدر: | Frontiers in Nutrition, Vol 11 (2024) |
| بيانات النشر: | Frontiers Media S.A., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | global leadership initiative on malnutrition, clinical nutrition, colorectal cancer, nomogram, clinical outcomes, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | BackgroundMalnutrition often occurs in patients with colorectal cancer. This study aims to develop a predictive model based on GLIM criteria for patients with colorectal cancer who underwent radical surgery.MethodsFrom December 2015 to May 2021, patients with colorectal cancer who underwent radical surgery at our center were recruited for this study. We prospectively collected data on GLIM-defined malnutrition and other clinicopathological characteristics. Using Cox regeneration, we developed a novel nomogram for prognostic prediction, which was validated and compared to traditional nutritional factors for predictive accuracy.ResultsAmong the 983 patients enrolled in this study, malnutrition was identified in 233 (23.70%) patients. Multivariate analysis indicated that GLIM-defined malnutrition is the independent risk factor for overall survival (HR = 1.793, 95% CI = 1.390–2.313 for moderate malnutrition and HR = 3.485, 95% CI = 2.087–5.818 for severe malnutrition). The novel nomogram based on the GLIM criteria demonstrated a better performance than existing criteria, with AUC of 0.729, 0.703, and 0.683 for 1-year, 3-year, and 5-year OS, respectively, in the validation cohort. In addition, the risk score determined by this system exhibited significantly poorer short-term and long-term clinical outcomes in high-risk groups in both malnourished and well-nourished patients.ConclusionCombining handgrip strength, serum albumin level, and TNM stage would help improve the predictive effect of GLIM criteria for colorectal cancer patients post-radical surgery and benefit the individual prognostic prediction of colorectal cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2296-861X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1425317/full; https://doaj.org/toc/2296-861X |
| DOI: | 10.3389/fnut.2024.1425317 |
| URL الوصول: | https://doaj.org/article/8bfccc90683845c38293726434ff959d |
| رقم الانضمام: | edsdoj.8bfccc90683845c38293726434ff959d |
| قاعدة البيانات: | Directory of Open Access Journals |
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