Academic Journal
أعرض في EDS

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer

التفاصيل البيبلوغرافية
العنوان: Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
المؤلفون: Qiushi Zhao, Xingyu Lin, Guan Wang
المصدر: Frontiers in Oncology, Vol 12 (2022)
بيانات النشر: Frontiers Media S.A., 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: SREBP-1, fatty acid synthase, fatty acids, lipogenesis, cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from the same gene for regulating the genes of lipogenesis, including acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase. Importantly, SREBP-1 participates in metabolic reprogramming of various cancers and has been a biomarker for the prognosis or drug efficacy for the patients with cancer. In this review, we first introduced the structure, activation, and key upstream signaling pathway of SREBP-1. Then, the potential targets and molecular mechanisms of SREBP-1-regulated lipogenesis in various types of cancer, such as colorectal, prostate, breast, and hepatocellular cancer, were summarized. We also discussed potential therapies targeting the SREBP-1-regulated pathway by small molecules, natural products, or the extracts of herbs against tumor progression. This review could provide new insights in understanding advanced findings about SREBP-1-mediated lipogenesis in cancer and its potential as a target for cancer therapeutics.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2234-943X
Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.952371/full; https://doaj.org/toc/2234-943X
DOI: 10.3389/fonc.2022.952371
URL الوصول: https://doaj.org/article/c823962675084b62893ad3004762c227
رقم الانضمام: edsdoj.823962675084b62893ad3004762c227
قاعدة البيانات: Directory of Open Access Journals
ResultId 1
Header edsdoj
Directory of Open Access Journals
edsdoj.823962675084b62893ad3004762c227
947
3
Academic Journal
academicJournal
947.127746582031
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.823962675084b62893ad3004762c227&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doaj.org/article/c823962675084b62893ad3004762c227 [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=2234943X&ISBN=&volume=12&issue=&date=20220701&spage=&pages=&title=Frontiers in Oncology&atitle=Targeting%20SREBP-1-Mediated%20Lipogenesis%20as%20Potential%20Strategies%20for%20Cancer&id=DOI:10.3389/fonc.2022.952371 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Qiushi+Zhao%22">Qiushi Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Xingyu+Lin%22">Xingyu Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Guan+Wang%22">Guan Wang</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Frontiers in Oncology, Vol 12 (2022) )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Frontiers Media S.A., 2022. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22SREBP-1%22">SREBP-1</searchLink><br /><searchLink fieldCode="DE" term="%22fatty+acid+synthase%22">fatty acid synthase</searchLink><br /><searchLink fieldCode="DE" term="%22fatty+acids%22">fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22lipogenesis%22">lipogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22cancer+therapy%22">cancer therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%2E+Tumors%2E+Oncology%2E+Including+cancer+and+carcinogens%22">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</searchLink><br /><searchLink fieldCode="DE" term="%22RC254-282%22">RC254-282</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from the same gene for regulating the genes of lipogenesis, including acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase. Importantly, SREBP-1 participates in metabolic reprogramming of various cancers and has been a biomarker for the prognosis or drug efficacy for the patients with cancer. In this review, we first introduced the structure, activation, and key upstream signaling pathway of SREBP-1. Then, the potential targets and molecular mechanisms of SREBP-1-regulated lipogenesis in various types of cancer, such as colorectal, prostate, breast, and hepatocellular cancer, were summarized. We also discussed potential therapies targeting the SREBP-1-regulated pathway by small molecules, natural products, or the extracts of herbs against tumor progression. This review could provide new insights in understanding advanced findings about SREBP-1-mediated lipogenesis in cancer and its potential as a target for cancer therapeutics. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2234-943X )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.frontiersin.org/articles/10.3389/fonc.2022.952371/full; https://doaj.org/toc/2234-943X )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.3389/fonc.2022.952371 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/c823962675084b62893ad3004762c227" linkWindow="_blank">https://doaj.org/article/c823962675084b62893ad3004762c227</link> )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.823962675084b62893ad3004762c227 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.3389/fonc.2022.952371 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => SREBP-1 [Type] => general ) [1] => Array ( [SubjectFull] => fatty acid synthase [Type] => general ) [2] => Array ( [SubjectFull] => fatty acids [Type] => general ) [3] => Array ( [SubjectFull] => lipogenesis [Type] => general ) [4] => Array ( [SubjectFull] => cancer therapy [Type] => general ) [5] => Array ( [SubjectFull] => Neoplasms. Tumors. Oncology. Including cancer and carcinogens [Type] => general ) [6] => Array ( [SubjectFull] => RC254-282 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Qiushi Zhao ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Xingyu Lin ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Guan Wang ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 07 [Type] => published [Y] => 2022 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 2234943X ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 12 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Frontiers in Oncology [Type] => main ) ) ) ) ) ) )
IllustrationInfo