Academic Journal
Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance in Campylobacter jejuni in Calves
| العنوان: | Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance in Campylobacter jejuni in Calves |
|---|---|
| المؤلفون: | Debora Brito Goulart, Ashenafi Feyisa Beyi, Zuowei Wu, Mehmet Cemal Adiguzel, Anastasia Schroeder, Kritika Singh, Changyun Xu, Melda Meral Ocal, Renee Dewell, Grant A. Dewell, Paul J. Plummer, Qijing Zhang, Orhan Sahin |
| المصدر: | Antibiotics, Vol 11, Iss 4, p 531 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Campylobacter, cattle, colonization, rectal feces, bovine respiratory disease (BRD), fluoroquinolone/danofloxacin treatment, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Campylobacter is a leading cause of foodborne gastroenteritis. Recent studies have indicated a rise in fluoroquinolone-resistant (FQ-R) Campylobacter in cattle, where FQ is used to control bovine respiratory disease (BRD). To assess the effect of danofloxacin treatment on the development of FQ-resistance in C. jejuni, 30 commercial calves were divided into Group 1, Group 2, and Group 3 (n = 10), and were all inoculated orally with FQ-susceptible (FQ-S) C. jejuni; seven days later, Group 3 was challenged with transtracheal Mannheimia haemolytica, and one week later, Group 2 and Group 3 were injected subcutaneously with danofloxacin. Rectal feces were collected to determine relative percentages of FQ-R Campylobacter via culture. Before oral inoculation with C. jejuni, 87% of calves were naturally colonized by FQ-R C. jejuni. Two days after the inoculation, FQ-R C. jejuni decreased substantially in the majority of calves. Within 24 h of danofloxacin injection, almost all C. jejuni populations shifted to an FQ-R phenotype in both FQ-treated groups, which was only transitory, as FQ-S strains became predominant during later periods. Genotyping indicated that the spike seen in FQ-R C. jejuni populations following the injection was due mainly to enrichment of preexisting FQ-R C. jejuni, rather than development of de novo FQ resistance in susceptible strains. These results provide important insights into the dynamic changes of FQ-resistant Campylobacter in cattle in response to FQ treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2079-6382 |
| Relation: | https://www.mdpi.com/2079-6382/11/4/531; https://doaj.org/toc/2079-6382 |
| DOI: | 10.3390/antibiotics11040531 |
| URL الوصول: | https://doaj.org/article/81bcd1eacd0c40f08fb47cdc87eb83c2 |
| رقم الانضمام: | edsdoj.81bcd1eacd0c40f08fb47cdc87eb83c2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edsdoj Directory of Open Access Journals edsdoj.81bcd1eacd0c40f08fb47cdc87eb83c2 917 3 Academic Journal academicJournal 917.363525390625 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.81bcd1eacd0c40f08fb47cdc87eb83c2&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://doaj.org/article/81bcd1eacd0c40f08fb47cdc87eb83c2 [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=20796382&ISBN=&volume=11&issue=4&date=20220401&spage=531&pages=531-531&title=Antibiotics&atitle=Effect%20of%20Danofloxacin%20Treatment%20on%20the%20Development%20of%20Fluoroquinolone%20Resistance%20in%20Campylobacter%20jejuni%20in%20Calves&id=DOI:10.3390/antibiotics11040531 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance in Campylobacter jejuni in Calves
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Debora+Brito+Goulart%22">Debora Brito Goulart</searchLink><br /><searchLink fieldCode="AR" term="%22Ashenafi+Feyisa+Beyi%22">Ashenafi Feyisa Beyi</searchLink><br /><searchLink fieldCode="AR" term="%22Zuowei+Wu%22">Zuowei Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Mehmet+Cemal+Adiguzel%22">Mehmet Cemal Adiguzel</searchLink><br /><searchLink fieldCode="AR" term="%22Anastasia+Schroeder%22">Anastasia Schroeder</searchLink><br /><searchLink fieldCode="AR" term="%22Kritika+Singh%22">Kritika Singh</searchLink><br /><searchLink fieldCode="AR" term="%22Changyun+Xu%22">Changyun Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Melda+Meral+Ocal%22">Melda Meral Ocal</searchLink><br /><searchLink fieldCode="AR" term="%22Renee+Dewell%22">Renee Dewell</searchLink><br /><searchLink fieldCode="AR" term="%22Grant+A%2E+Dewell%22">Grant A. Dewell</searchLink><br /><searchLink fieldCode="AR" term="%22Paul+J%2E+Plummer%22">Paul J. Plummer</searchLink><br /><searchLink fieldCode="AR" term="%22Qijing+Zhang%22">Qijing Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Orhan+Sahin%22">Orhan Sahin</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Antibiotics, Vol 11, Iss 4, p 531 (2022) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => MDPI AG, 2022. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Therapeutics. Pharmacology ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Campylobacter%22">Campylobacter</searchLink><br /><searchLink fieldCode="DE" term="%22cattle%22">cattle</searchLink><br /><searchLink fieldCode="DE" term="%22colonization%22">colonization</searchLink><br /><searchLink fieldCode="DE" term="%22rectal+feces%22">rectal feces</searchLink><br /><searchLink fieldCode="DE" term="%22bovine+respiratory+disease+%28BRD%29%22">bovine respiratory disease (BRD)</searchLink><br /><searchLink fieldCode="DE" term="%22fluoroquinolone%2Fdanofloxacin+treatment%22">fluoroquinolone/danofloxacin treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Campylobacter is a leading cause of foodborne gastroenteritis. Recent studies have indicated a rise in fluoroquinolone-resistant (FQ-R) Campylobacter in cattle, where FQ is used to control bovine respiratory disease (BRD). To assess the effect of danofloxacin treatment on the development of FQ-resistance in C. jejuni, 30 commercial calves were divided into Group 1, Group 2, and Group 3 (n = 10), and were all inoculated orally with FQ-susceptible (FQ-S) C. jejuni; seven days later, Group 3 was challenged with transtracheal Mannheimia haemolytica, and one week later, Group 2 and Group 3 were injected subcutaneously with danofloxacin. Rectal feces were collected to determine relative percentages of FQ-R Campylobacter via culture. Before oral inoculation with C. jejuni, 87% of calves were naturally colonized by FQ-R C. jejuni. Two days after the inoculation, FQ-R C. jejuni decreased substantially in the majority of calves. Within 24 h of danofloxacin injection, almost all C. jejuni populations shifted to an FQ-R phenotype in both FQ-treated groups, which was only transitory, as FQ-S strains became predominant during later periods. Genotyping indicated that the spike seen in FQ-R C. jejuni populations following the injection was due mainly to enrichment of preexisting FQ-R C. jejuni, rather than development of de novo FQ resistance in susceptible strains. These results provide important insights into the dynamic changes of FQ-resistant Campylobacter in cattle in response to FQ treatment. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article ) Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2079-6382 ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.mdpi.com/2079-6382/11/4/531; https://doaj.org/toc/2079-6382 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.3390/antibiotics11040531 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/81bcd1eacd0c40f08fb47cdc87eb83c2" linkWindow="_blank">https://doaj.org/article/81bcd1eacd0c40f08fb47cdc87eb83c2</link> ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.81bcd1eacd0c40f08fb47cdc87eb83c2 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.3390/antibiotics11040531
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 1
[StartPage] => 531
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Campylobacter
[Type] => general
)
[1] => Array
(
[SubjectFull] => cattle
[Type] => general
)
[2] => Array
(
[SubjectFull] => colonization
[Type] => general
)
[3] => Array
(
[SubjectFull] => rectal feces
[Type] => general
)
[4] => Array
(
[SubjectFull] => bovine respiratory disease (BRD)
[Type] => general
)
[5] => Array
(
[SubjectFull] => fluoroquinolone/danofloxacin treatment
[Type] => general
)
[6] => Array
(
[SubjectFull] => Therapeutics. Pharmacology
[Type] => general
)
[7] => Array
(
[SubjectFull] => RM1-950
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Effect of Danofloxacin Treatment on the Development of Fluoroquinolone Resistance in Campylobacter jejuni in Calves
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Debora Brito Goulart
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ashenafi Feyisa Beyi
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Zuowei Wu
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mehmet Cemal Adiguzel
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Anastasia Schroeder
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kritika Singh
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Changyun Xu
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Melda Meral Ocal
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Renee Dewell
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Grant A. Dewell
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Paul J. Plummer
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Qijing Zhang
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Orhan Sahin
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 04
[Type] => published
[Y] => 2022
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 20796382
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 11
)
[1] => Array
(
[Type] => issue
[Value] => 4
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Antibiotics
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |