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Clinical efficacy of Danshen preparation in the treatment of vascular cognitive impairment: A systematic review and meta-analysis

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العنوان: Clinical efficacy of Danshen preparation in the treatment of vascular cognitive impairment: A systematic review and meta-analysis
المؤلفون: Yunze Li, Yangjing Yao, Xinran Cao, Nan Yi, Anqi Chen, Jianjun Li, Minghua Wu
المصدر: Frontiers in Aging Neuroscience, Vol 14 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: Danshen preparation, vascular cognitive performance, clinical studies, systematic review, meta-analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Ethnopharmacological relevanceDanshen preparations are widely used in the treatment of ischaemic cerebrovascular disease. However, the clinical efficacy of such preparations remains unclear. Consequently, Danshen preparations are used to a lesser extent in vascular cognitive impairment (VCI).Aim of the studyIn this study, we aimed to systematically assess the clinical efficacy and safety of Danshen preparations in VCI. To this end, we examined and performed a meta-analysis (MA) of the evidence available from randomised controlled trials (RCTs) of Danshen preparations conducted in patients with VCI.MethodsWe queried the following sources and collected all articles reporting on RCTs of Danshen preparations published prior to December 2021: PubMed, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chongqing VIP Database (CQVIP), and China Biology Medicine (CBM) disc databases. The assessment of treatments that were included in references were performed by RevMan 5.2 software based on guidelines from Cochrane Handbook for Systematic Reviews of Interventions.ResultsWe included a total of 12 RCTs that included data on clinical therapeutic effects. The evaluation criteria included the following: National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI), Mini-Mental State Assessment (MMSE), Montreal Cognitive Assessment (MOCA), Activities of Daily Living Scale (ADL), treatment effect index, and incidence of adverse reaction index. In the included studies, the observation groups included 656 cases and the control groups included 660 cases. The results of the MA were as follows: the mean difference (MD) value after combining the effect size for NIHSS was −2.91, with a 95% confidence interval (CI) of −4.22 to −1.59; the combined effect quantity hypothesis test revealed that Z = 4.33 (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1663-4365
Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2022.1090665/full; https://doaj.org/toc/1663-4365
DOI: 10.3389/fnagi.2022.1090665
URL الوصول: https://doaj.org/article/7ffd77b908424f89b96ba11aa153c94f
رقم الانضمام: edsdoj.7ffd77b908424f89b96ba11aa153c94f
قاعدة البيانات: Directory of Open Access Journals
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