Academic Journal
أعرض في EDS

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression

التفاصيل البيبلوغرافية
العنوان: AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression
المؤلفون: Pablo Oppezzo, Marcelo Navarrete, Nicholas Chiorazzi
المصدر: Frontiers in Oncology, Vol 11 (2021)
بيانات النشر: Frontiers Media S.A., 2021.
سنة النشر: 2021
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: AID, CLL, microenvironment, off-target mutations, SHM, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions for an effective adaptive immune response. However, in addition to the benefits generated by its physiological roles, AID is an etiological factor for the development of human and murine leukemias and lymphomas. This review highlights the pathological role of AID and the consequences of its actions on the development, progression, and therapeutic refractoriness of chronic lymphocytic leukemia (CLL) as a model disease for mature lymphoid malignancies. First, we summarize pertinent aspects of the expression and function of AID in normal B lymphocytes. Then, we assess putative causes for AID expression in leukemic cells emphasizing the role of an activated microenvironment. Thirdly, we discuss the role of AID in lymphomagenesis, in light of recent data obtained by NGS analyses on the genomic landscape of leukemia and lymphomas, concentrating on the frequency of AID signatures in these cancers and correlating previously described tumor-gene drivers with the presence of AID off-target mutations. Finally, we discuss how these changes could affect tumor suppressor and proto-oncogene targets and how they could be associated with disease progression. Collectively, we hope that these sections will help to better understand the complex paradox between the physiological role of AID in adaptive immunity and its potential causative activity in B-cell malignancies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2234-943X
Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.634383/full; https://doaj.org/toc/2234-943X
DOI: 10.3389/fonc.2021.634383
URL الوصول: https://doaj.org/article/7a5957feabb046e49dd246d6ebcef9ad
رقم الانضمام: edsdoj.7a5957feabb046e49dd246d6ebcef9ad
قاعدة البيانات: Directory of Open Access Journals
ResultId 1
Header edsdoj
Directory of Open Access Journals
edsdoj.7a5957feabb046e49dd246d6ebcef9ad
924
3
Academic Journal
academicJournal
923.723937988281
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.7a5957feabb046e49dd246d6ebcef9ad&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doaj.org/article/7a5957feabb046e49dd246d6ebcef9ad [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=2234943X&ISBN=&volume=11&issue=&date=20210501&spage=&pages=&title=Frontiers in Oncology&atitle=AID%20in%20Chronic%20Lymphocytic%20Leukemia%3A%20Induction%20and%20Action%20During%20Disease%20Progression&id=DOI:10.3389/fonc.2021.634383 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Pablo+Oppezzo%22">Pablo Oppezzo</searchLink><br /><searchLink fieldCode="AR" term="%22Marcelo+Navarrete%22">Marcelo Navarrete</searchLink><br /><searchLink fieldCode="AR" term="%22Nicholas+Chiorazzi%22">Nicholas Chiorazzi</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Frontiers in Oncology, Vol 11 (2021) )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Frontiers Media S.A., 2021. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22AID%22">AID</searchLink><br /><searchLink fieldCode="DE" term="%22CLL%22">CLL</searchLink><br /><searchLink fieldCode="DE" term="%22microenvironment%22">microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22off-target+mutations%22">off-target mutations</searchLink><br /><searchLink fieldCode="DE" term="%22SHM%22">SHM</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%2E+Tumors%2E+Oncology%2E+Including+cancer+and+carcinogens%22">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</searchLink><br /><searchLink fieldCode="DE" term="%22RC254-282%22">RC254-282</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions for an effective adaptive immune response. However, in addition to the benefits generated by its physiological roles, AID is an etiological factor for the development of human and murine leukemias and lymphomas. This review highlights the pathological role of AID and the consequences of its actions on the development, progression, and therapeutic refractoriness of chronic lymphocytic leukemia (CLL) as a model disease for mature lymphoid malignancies. First, we summarize pertinent aspects of the expression and function of AID in normal B lymphocytes. Then, we assess putative causes for AID expression in leukemic cells emphasizing the role of an activated microenvironment. Thirdly, we discuss the role of AID in lymphomagenesis, in light of recent data obtained by NGS analyses on the genomic landscape of leukemia and lymphomas, concentrating on the frequency of AID signatures in these cancers and correlating previously described tumor-gene drivers with the presence of AID off-target mutations. Finally, we discuss how these changes could affect tumor suppressor and proto-oncogene targets and how they could be associated with disease progression. Collectively, we hope that these sections will help to better understand the complex paradox between the physiological role of AID in adaptive immunity and its potential causative activity in B-cell malignancies. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2234-943X )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.frontiersin.org/articles/10.3389/fonc.2021.634383/full; https://doaj.org/toc/2234-943X )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.3389/fonc.2021.634383 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/7a5957feabb046e49dd246d6ebcef9ad" linkWindow="_blank">https://doaj.org/article/7a5957feabb046e49dd246d6ebcef9ad</link> )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.7a5957feabb046e49dd246d6ebcef9ad )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.3389/fonc.2021.634383 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => AID [Type] => general ) [1] => Array ( [SubjectFull] => CLL [Type] => general ) [2] => Array ( [SubjectFull] => microenvironment [Type] => general ) [3] => Array ( [SubjectFull] => off-target mutations [Type] => general ) [4] => Array ( [SubjectFull] => SHM [Type] => general ) [5] => Array ( [SubjectFull] => Neoplasms. Tumors. Oncology. Including cancer and carcinogens [Type] => general ) [6] => Array ( [SubjectFull] => RC254-282 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pablo Oppezzo ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Marcelo Navarrete ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nicholas Chiorazzi ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 05 [Type] => published [Y] => 2021 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 2234943X ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 11 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Frontiers in Oncology [Type] => main ) ) ) ) ) ) )
IllustrationInfo