Academic Journal
Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer
| العنوان: | Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer |
|---|---|
| المؤلفون: | Csilla Olah, Henning Reis, Michèle J. Hoffmann, Fabian Mairinger, Saskia Ting, Boris Hadaschik, Ulrich Krafft, Viktor Grünwald, Peter Nyirady, Melinda Varadi, Balázs Győrffy, Andras Kiss, Eszter Szekely, Gottfrid Sjödahl, Tibor Szarvas |
| المصدر: | Cancer Medicine, Vol 12, Iss 5, Pp 5222-5232 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | APOBEC3G, bladder cancer, cisplatin, molecular subtype classification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Objective Although targeted approaches have become available in second‐ and third‐line settings, platinum‐based chemotherapy remains the standard first‐line treatment for advanced muscle‐invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods In this study, we established a routine compatible method for the molecular classification of MIBC samples according to various classification systems and applied this method to evaluate the impact of subtypes on survival after adjuvant chemotherapy. This retrospective study included 191 patients with advanced MIBC (pT≥3 or pN+) who underwent radical cystectomy, with or without adjuvant chemotherapy. A 48‐gene panel and classifier rule set were established to determine molecular subtypes according to TCGA, MDA, LundTax, and Consensus classifications. Additionally, 12 single platinum‐predictive candidate genes were assessed. The results were correlated with patients' clinicopathological and follow‐up data and were validated using independent data sets. Results Our final evaluation of 159 patients demonstrated better survival in the luminal groups for those who received chemotherapy compared with those who did not. In contrast, no such differences were observed in basal subtypes. The use of chemotherapy was associated with better survival in patients with high APOBEC3G expression (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-7634 |
| Relation: | https://doaj.org/toc/2045-7634 |
| DOI: | 10.1002/cam4.5324 |
| URL الوصول: | https://doaj.org/article/7547c69a833c47a98b4d560264ca3735 |
| رقم الانضمام: | edsdoj.7547c69a833c47a98b4d560264ca3735 |
| قاعدة البيانات: | Directory of Open Access Journals |
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