Academic Journal
Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
| العنوان: | Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents |
|---|---|
| المؤلفون: | Csilla Enikő Szabo, Oana Iulia Man, Alexandru Istrate, Eva Kiss, Andreea Catana, Victoria Creț, Radu Sorin Șerban, Ioan Victor Pop |
| المصدر: | Diagnostics, Vol 10, Iss 11, p 945 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | adiponectin, tumor necrosis factor-alpha, type 1 diabetes mellitus, Medicine (General), R5-920 |
| الوصف: | Type 1 diabetes mellitus (T1DM) is a complex condition caused by the destruction of pancreatic beta cells by autoimmune mechanisms. As a result, insulin deficiency and subsequent hyperglycemia occur. The aim of the present study is to investigate the role of adiponectin and tumor necrosis factor alpha (TNF-α) in the development of T1DM. The study is designed as an observational case-control study, involving 52 diabetic patients and 66 controls. Z scores for Body Mass Index (BMI), weight, height, and adiponectin and TNF-α serum levels were assessed in both groups. The T1DM group had significantly higher TNF-α levels and a significantly higher proportion of high-risk patients for inflammation based on TNF-α values as compared to the control group, while both groups had statistically similar adiponectin levels and a similar proportion of high/medium-risk patients based on adiponectin values. TNF-α plays a significant role in the pathogenesis and evolution of T1DM and it may represent an additional marker of disease progression, as well as a potential target of immunotherapeutic strategies. In the present study, no statistically significant differences were recorded in adiponectin levels neither in diabetic patients and controls, nor in high/medium severity risk diabetic patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2075-4418 |
| Relation: | https://www.mdpi.com/2075-4418/10/11/945; https://doaj.org/toc/2075-4418 |
| DOI: | 10.3390/diagnostics10110945 |
| URL الوصول: | https://doaj.org/article/7470eb76f4894638a0032134dcac1c85 |
| رقم الانضمام: | edsdoj.7470eb76f4894638a0032134dcac1c85 |
| قاعدة البيانات: | Directory of Open Access Journals |
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