Academic Journal
Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice
| العنوان: | Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice |
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| المؤلفون: | Ji Hyeon Ahn, Dae Won Kim, Cheol Woo Park, Bora Kim, Hyejin Sim, Hyun Sook Kim, Tae-Kyeong Lee, Jae-Chul Lee, Go Eun Yang, Young Her, Joon Ha Park, Tae Heung Sim, Hyun Sam Lee, Moo-Ho Won |
| المصدر: | Marine Drugs, Vol 18, Iss 7, p 345 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | antioxidants, collagen fiber, epidermal thickness, laminarin, oxidative stress, UVB, Biology (General), QH301-705.5 |
| الوصف: | A number of studies have demonstrated that marine carbohydrates display anti-oxidant, anti-melanogenic, and anti-aging activities in the skin. Laminarin (LA), a low-molecular-weight polysaccharide, is found in brown algae. The benefits of LA in ultraviolet B (UVB) induced photodamage of the skin have not been reported. The aim of this study was to investigate the effects of pre-treated LA on histopathological changes and oxidative damage in mouse dorsal skin on day 5, following repeated UVB exposure. Histopathology, Western blot analysis and immunohistochemical studies showed that epidermal thickness in the UVB group was significantly increased; however, the thickness in the UVB group treated with LA (LA/UVB group) was less compared with that of the UVB group. Collagen fibers in the dermis of the UVB group were significantly decreased and destroyed, whereas, in the LA/UVB group, the density of collagen fibers was significantly increased compared with that of the UVB group. Oxidative stress due to superoxide anion production measured via dihydroethidium fluorescence staining was dramatically increased in the UVB group, whereas in the LA/UVB group, the oxidative stress was significantly decreased. Expressions of SOD1, glutathione peroxidase and catalase were markedly reduced in the UVB group, whereas in the LA/UVB group, they were significantly higher along with SOD2 than in the control group. Taken together, our results indicate that LA pretreatment prevents or attenuates skin damage, by decreasing oxidative stress and increasing antioxidant enzymes in mouse dorsal skin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 18070345 1660-3397 |
| Relation: | https://www.mdpi.com/1660-3397/18/7/345; https://doaj.org/toc/1660-3397 |
| DOI: | 10.3390/md18070345 |
| URL الوصول: | https://doaj.org/article/7277b9f4ccf24fdfb2196db490fe53ed |
| رقم الانضمام: | edsdoj.7277b9f4ccf24fdfb2196db490fe53ed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18070345 16603397 |
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| DOI: | 10.3390/md18070345 |