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Spreading depolarization evoked by endothelin-1 is inhibited by octanol but not by carbenoxolone

التفاصيل البيبلوغرافية
العنوان: Spreading depolarization evoked by endothelin-1 is inhibited by octanol but not by carbenoxolone
المؤلفون: Gabor C. Petzold, Jens P. Dreier
المصدر: Brain Hemorrhages, Vol 2, Iss 1, Pp 6-14 (2021)
بيانات النشر: KeAi Communications Co., Ltd., 2021.
سنة النشر: 2021
المجموعة: LCC:Neurophysiology and neuropsychology
مصطلحات موضوعية: Subarachnoid hemorrhage, Delayed cerebral ischemia, Gap junctions, Spreading depolarization, Endothelin-1, Neurophysiology and neuropsychology, QP351-495
الوصف: Spreading depolarization (SD) has been implicated in the pathogenesis of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. Endothelin-1 (ET-1) is a powerful trigger of SD and may be involved in DCI. The SD-causing mechanism is assumed to result from ET-1-induced microarterial spasm and ischemia. However, ET-1 is also a potent, astrocyte-specific gap junction (GJ) inhibitor. There are two competing hypotheses on the role of astrocytic GJs in SD. One postulates that they mediate SDs, since long-chain alcohols such as octanol inhibit GJs and inhibit SD at high concentrations. The other postulates that astrocytic GJs protect against SD and that their inhibition increases susceptibility to SD and SD velocity. Here, we found in rats that brain topical application of carbenoxolone, a more specific GJ inhibitor, failed to inhibit ET-1-induced SDs in vivo, whereas octanol, a less specific GJ inhibitor, partially blocked them at high concentrations. These results suggest that GJs are not required for initiation or propagation of ET-1-induced SDs, and that octanol inhibits SDs by effects unrelated to GJs. The results do not exclude that the specific inhibition of astrocytic GJs by ET-1 contributes to the generation of SDs, which should be further investigated in future studies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2589-238X
Relation: http://www.sciencedirect.com/science/article/pii/S2589238X20300425; https://doaj.org/toc/2589-238X
DOI: 10.1016/j.hest.2020.08.002
URL الوصول: https://doaj.org/article/6f31d5208be849d9bd6f47701a029c4e
رقم الانضمام: edsdoj.6f31d5208be849d9bd6f47701a029c4e
قاعدة البيانات: Directory of Open Access Journals
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