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Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).

التفاصيل البيبلوغرافية
العنوان: Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).
المؤلفون: Laura Lee, Richard Seager, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley
المصدر: PLoS ONE, Vol 14, Iss 5, p e0213116 (2019)
بيانات النشر: Public Library of Science (PLoS), 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The mitochondrial outer membrane protein Mitochondrial Fission Factor (Mff) plays a key role in both physiological and pathological fission. It is well established that at stressed or functionally impaired mitochondria, PINK1 recruits the ubiquitin ligase Parkin which ubiquitinates Mff and other mitochondrial outer membrane proteins to facilitate the removal of defective mitochondria and maintain the integrity of the mitochondrial network. Here we show that, in addition to this clearance pathway, Parkin also ubiquitinates Mff in a PINK1-dependent manner under non-stressed conditions to regulate constitutive Mff turnover. We further show that removing Parkin via shRNA-mediated knockdown does not completely prevent Mff ubiquitination under these conditions, indicating that at least one other ubiquitin ligase contributes to Mff proteostasis. These data suggest that that Parkin plays a role in physiological maintenance of mitochondrial membrane protein composition in unstressed cells through constitutive low-level activation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0213116
URL الوصول: https://doaj.org/article/6c742171d014421094ee11e2ae2330f9
رقم الانضمام: edsdoj.6c742171d014421094ee11e2ae2330f9
قاعدة البيانات: Directory of Open Access Journals
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