التفاصيل البيبلوغرافية
| العنوان: |
Plasma Interleukin-6 Level: A Potential Prognostic Indicator of Emergent HBV-Associated ACLF |
| المؤلفون: |
Zhe-Bin Wu, Yu-Bao Zheng, Ke Wang, Zhi-Shuo Mo, Xu Zhen, Ying Yan, Zhi-Liang Gao |
| المصدر: |
Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021) |
| بيانات النشر: |
Hindawi Limited, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: |
Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: |
Objective. To identify markers that predict the progression to hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods. We recruited 125 patients with chronic hepatitis B (CHB) between September 2013 and March 2017. During hospitalization, 25 patients progressed to LF and were classified as the LF group, while the remaining 100 patients were classified as the non-LF (NLF) group. We compared the kinetic changes in clinical and immune indicators including age, total bilirubin level, prothrombin time, model for end-stage liver disease score, interleukin (IL)-6, IL-8, and IL-10 cytokine levels, and number of T helper 17 and regulatory T cells between groups to determine their association with progression to HBV-ACLF. The prognostic value of clinical and immune indicators was determined using the area under the receiver operating characteristic curve (AUC) value. Results. Cox regression analysis suggested that the plasma IL-6 level could predict CHB progression to HBV-ACLF (relative risk = 1.082, 95% confidence interval: 1.006–1.164; P=0.034). The AUC value, sensitivity, and specificity of baseline IL-6 level for predicting HBV-ACLF were 82.63%, 83.3%, and 82.9%, respectively (P=0.001). Conclusion. A high plasma IL-6 level in CHB patients could be an early biomarker for HBV-ACLF. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2291-2797 |
| Relation: |
https://doaj.org/toc/2291-2797 |
| DOI: |
10.1155/2021/5545181 |
| URL الوصول: |
https://doaj.org/article/63aee7813af74e518eb2bd218aa1c15c |
| رقم الانضمام: |
edsdoj.63aee7813af74e518eb2bd218aa1c15c |
| قاعدة البيانات: |
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