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Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up

التفاصيل البيبلوغرافية
العنوان: Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up
المؤلفون: Hiroaki Kanno, Kyoko Ishida, Wataru Yamada, Ikumi Shiraki, Hiroki Murase, Yuka Yamagishi, Kiyofumi Mochizuki
المصدر: Journal of Ophthalmology, Vol 2018 (2018)
بيانات النشر: Hindawi Limited, 2018.
سنة النشر: 2018
المجموعة: LCC:Ophthalmology
مصطلحات موضوعية: Ophthalmology, RE1-994
الوصف: Purpose. To investigate the clinical manifestations, prognosis, and HLA-type of tubulointerstitial nephritis and uveitis syndrome (TINU) with long-term follow-up. Methods. Clinical data of five patients with TINU were retrospectively reviewed. Results. The mean age was 15.8 years. The mean follow-up periods were 54.0 months. The initial subjective symptoms were bulbar injection (100%), ocular pain (80%), and blurred vision (60%). The medical department that the patients visited first was ophthalmology in 4 (80%) cases. Urinalysis showed the characteristic increase of the β2 microglobulin in all (100%) patients. Uveitis and nephritis were diagnosed within 1 week from each other. Although two showed recurrences, the topical and systemic steroid treatment with mean duration of 14.1 months brought the resolution of nephritis and uveitis in all patients. Recurrence-free periods ranged from 12 to 71 months. The final visual outcome was 20/20 or better in all cases. HLA-DR4 or the allele of DRB1∗04 was present in all (100%) patients. Conclusions. TINU should be considered in the differential diagnosis in young patients with uveitis of unknown origin and renal dysfunction. Urinary β2 microglobulin level and HLA typing may help in the diagnosis of TINU. The prognosis for patients with TINU is generally good with steroid treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-004X
2090-0058
Relation: https://doaj.org/toc/2090-004X; https://doaj.org/toc/2090-0058
DOI: 10.1155/2018/4586532
URL الوصول: https://doaj.org/article/634f2bf7c6ba47059b4cbc82acbbd153
رقم الانضمام: edsdoj.634f2bf7c6ba47059b4cbc82acbbd153
قاعدة البيانات: Directory of Open Access Journals
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