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Intraperitoneal lactate/pyruvate ratio and the level of glucose and glycerol concentration differ between patients surgically treated for upper and lower perforations of the gastrointestinal tract: a pilot study

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العنوان: Intraperitoneal lactate/pyruvate ratio and the level of glucose and glycerol concentration differ between patients surgically treated for upper and lower perforations of the gastrointestinal tract: a pilot study
المؤلفون: Jonas E. Sabroe, Anne R. Axelsen, Mark B. Ellebæk, Bjarne Dahler-Eriksen, Niels Qvist
المصدر: BMC Research Notes, Vol 10, Iss 1, Pp 1-9 (2017)
بيانات النشر: BMC, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Biology (General)
LCC:Science (General)
مصطلحات موضوعية: Glycerol, Intraperitoneal microdialysis, Lactate/pyruvate ratio, Lactate/glucose ratio, Peritonitis, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
الوصف: Abstract Background Secondary peritonitis is a condition associated with high morbidity and mortality. Continuous postoperative monitoring of patients to ensure timely intervention to treat complications without delay is important for survival and outcome. We aimed to (1) investigate potential differences in postoperative intraperitoneal biomarker levels between patients with upper and lower gastrointestinal tract lesion, and (2) compare postoperative biomarker levels between complicated and uncomplicated patients. Methods We included a total of 15 consecutive patients operated for upper (n = 7) and lower (n = 8) gastrointestinal tract perforation. We registered postoperative complications during a 30 days follow up-period. Complications were defined as intraabdominal complications, septic shock, and mortality. 5 patients were complicated. A microdialysis catheter was placed intraperitoneally in each patient. Samples were collected every 4th hour for up to 7 postoperative days. Samples were analysed for concentrations of glucose, lactate, pyruvate and glycerol. Results Microdialysis results showed that patients with upper gastrointestinal tract lesions had significantly higher levels of postoperative intraperitoneal glucose and glycerol concentrations, as well as lower lactate/pyruvate ratios and lactate/glucose ratios. In the group with perforation of the lower gastrointestinal tract, those patients with a complicated course showed lower levels of postoperative intraperitoneal glucose concentration and glycerol concentration and higher lactate/pyruvate ratios and lactate/glucose ratios than those patients with an uncomplicated course. Conclusion Patients with upper and lower gastrointestinal tract lesions showed differences in postoperative biomarker levels. A difference was also seen between patients with complicated and uncomplicated postoperative courses.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-0500
Relation: http://link.springer.com/article/10.1186/s13104-017-2622-9; https://doaj.org/toc/1756-0500
DOI: 10.1186/s13104-017-2622-9
URL الوصول: https://doaj.org/article/5e61a9131d3b403a8acc63d924145a68
رقم الانضمام: edsdoj.5e61a9131d3b403a8acc63d924145a68
قاعدة البيانات: Directory of Open Access Journals
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