Academic Journal
Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine
| العنوان: | Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine |
|---|---|
| المؤلفون: | Xing Huang, Gang Zhang, Tian-Yu Tang, Xiang Gao, Ting-Bo Liang |
| المصدر: | Military Medical Research, Vol 9, Iss 1, Pp 1-17 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Military Science |
| مصطلحات موضوعية: | Pancreatic cancer, Precise therapy, Cancer vaccine, mRNA vaccine, Tumor antigen, Immune subtype, Medicine (General), R5-920, Military Science |
| الوصف: | Abstract Pancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity, especially in genetic alteration and microenvironment. Conventional therapeutic strategies for pancreatic cancer usually suffer resistance, highlighting the necessity for personalized precise treatment. Cancer vaccines have become promising alternatives for pancreatic cancer treatment because of their multifaceted advantages including multiple targeting, minimal nonspecific effects, broad therapeutic window, low toxicity, and induction of persistent immunological memory. Multiple conventional vaccines based on the cells, microorganisms, exosomes, proteins, peptides, or DNA against pancreatic cancer have been developed; however, their overall efficacy remains unsatisfactory. Compared with these vaccine modalities, messager RNA (mRNA)-based vaccines offer technical and conceptional advances in personalized precise treatment, and thus represent a potentially cutting-edge option in novel therapeutic approaches for pancreatic cancer. This review summarizes the current progress on pancreatic cancer vaccines, highlights the superiority of mRNA vaccines over other conventional vaccines, and proposes the viable tactic for designing and applying personalized mRNA vaccines for the precise treatment of pancreatic cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2054-9369 41050940 |
| Relation: | https://doaj.org/toc/2054-9369 |
| DOI: | 10.1186/s40779-022-00416-w |
| URL الوصول: | https://doaj.org/article/a59abd410509400fb6b494d91b267cea |
| رقم الانضمام: | edsdoj.59abd410509400fb6b494d91b267cea |
| قاعدة البيانات: | Directory of Open Access Journals |
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