Academic Journal
In patients with severe asthma with eosinophilia in reslizumab clinical trials, high peripheral blood eosinophil levels are associated with low FEV1 reversibility
| العنوان: | In patients with severe asthma with eosinophilia in reslizumab clinical trials, high peripheral blood eosinophil levels are associated with low FEV1 reversibility |
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| المؤلفون: | J. Christian Virchow, Lisa Hickey, Evelyn Du, Margaret Garin |
| المصدر: | Allergy, Asthma & Clinical Immunology, Vol 16, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Asthma, Clinical trials, Eosinophils, Lung function, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Abstract Background A post hoc analysis of two randomized, placebo–controlled, Phase 3 trials of intravenous reslizumab, an anti-interleukin-5 (IL-5) biologic for severe eosinophilic asthma. Methods Relationships between baseline blood eosinophil levels (EOS), forced expiratory volume in 1 s (FEV1) reversibility to β2-agonists and treatment outcomes were assessed. Results Mean baseline FEV1 reversibility was numerically lower among patients with high (≥ 400 cells/µL) versus low baseline EOS. Reslizumab produced clinically significant improvement in FEV1, exacerbation rates and patient-reported outcomes after 52 weeks, including in patients with high EOS and low FEV1 reversibility (≤ 14%) to β2-agonists at baseline. Conclusions Clinical trial eligibility criteria stipulating minimum FEV1 reversibility to β2-agonists of ≥ 12% might exclude patients who would benefit from treatment with anti-IL-5 biologics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1710-1492 |
| Relation: | http://link.springer.com/article/10.1186/s13223-020-00424-2; https://doaj.org/toc/1710-1492 |
| DOI: | 10.1186/s13223-020-00424-2 |
| URL الوصول: | https://doaj.org/article/50d1273204b643ed93e6c67328950ea6 |
| رقم الانضمام: | edsdoj.50d1273204b643ed93e6c67328950ea6 |
| قاعدة البيانات: | Directory of Open Access Journals |
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