Academic Journal
Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer
| العنوان: | Challenges in Implementing Comprehensive Precision Medicine Screening for Ovarian Cancer |
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| المؤلفون: | Laura R. Moffitt, Nazanin Karimnia, Amy L. Wilson, Andrew N. Stephens, Gwo-Yaw Ho, Maree Bilandzic |
| المصدر: | Current Oncology, Vol 31, Iss 12, Pp 8023-8038 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | precision medicine, epithelial ovarian cancer, tumour heterogeneity, genomic screening, high-throughput drug screening, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Precision medicine has revolutionised targeted cancer treatments; however, its implementation in ovarian cancer remains challenging. Diverse tumour biology and extensive heterogeneity in ovarian cancer can limit the translatability of genetic profiling and contribute to a lack of biomarkers of treatment response. This review addresses the barriers in precision medicine for ovarian cancer, including obtaining adequate and representative tissue samples for analysis, developing functional and standardised screening methods, and navigating data infrastructure and management. Ethical concerns related to patient consent, data privacy and health equity are also explored. We highlight the socio-economic complexities for precision medicine and propose strategies to overcome these challenges with an emphasis on accessibility and education amongst patients and health professionals and the development of regulatory frameworks to support clinical integration. Interdisciplinary collaboration is essential to drive progress in precision medicine to improve disease management and ovarian cancer patient outcomes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1718-7729 1198-0052 |
| Relation: | https://www.mdpi.com/1718-7729/31/12/592; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
| DOI: | 10.3390/curroncol31120592 |
| URL الوصول: | https://doaj.org/article/4f042cb8f7754142a4837315f4d1066f |
| رقم الانضمام: | edsdoj.4f042cb8f7754142a4837315f4d1066f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol31120592 |