Academic Journal
Host genetics predict clinical deterioration in HCV-related cirrhosis.
| العنوان: | Host genetics predict clinical deterioration in HCV-related cirrhosis. |
|---|---|
| المؤلفون: | Lindsay Y King, Kara B Johnson, Hui Zheng, Lan Wei, Thomas Gudewicz, Yujin Hoshida, Kathleen E Corey, Tokunbo Ajayi, Nneka Ufere, Thomas F Baumert, Andrew T Chan, Kenneth K Tanabe, Bryan C Fuchs, Raymond T Chung |
| المصدر: | PLoS ONE, Vol 9, Iss 12, p e114747 (2014) |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. We genotyped SNPs in EGF, PNPLA3, and IL28B from liver tissue from 169 patients with biopsy-proven HCV cirrhosis. We estimated risk of clinical deterioration, defined as development of ascites, encephalopathy, variceal hemorrhage, HCC, or liver-related death using Cox proportional hazards modeling. During a median follow-up of 6.6 years, 66 of 169 patients experienced clinical deterioration. EGF non-AA, PNPLA3 non-CC, and IL28B non-CC genotypes were each associated with increased risk of clinical deterioration in age, sex, and race-adjusted analysis. Only EGF non-AA genotype was independently associated with increased risk of clinical deterioration (hazard ratio [HR] 2.87; 95% confidence interval [CI] 1.31-6.25) after additionally adjusting for bilirubin, albumin, and platelets. Compared to subjects who had 0-1 unfavorable genotypes, the HR for clinical deterioration was 1.79 (95%CI 0.96-3.35) for 2 unfavorable genotypes and 4.03 (95%CI 2.13-7.62) for unfavorable genotypes for all three loci (Ptrend |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0114747 |
| URL الوصول: | https://doaj.org/article/497ea6c6d0304258b7a004b7cf4c1256 |
| رقم الانضمام: | edsdoj.497ea6c6d0304258b7a004b7cf4c1256 |
| قاعدة البيانات: | Directory of Open Access Journals |
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