Academic Journal
Clinical Applications of Liquid Biopsy in Gastric Cancer
| العنوان: | Clinical Applications of Liquid Biopsy in Gastric Cancer |
|---|---|
| المؤلفون: | Mihaela Chivu-Economescu, Laura Necula, Lilia Matei, Denisa Dragu, Coralia Bleotu, Carmen C. Diaconu |
| المصدر: | Frontiers in Medicine, Vol 8 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | liquid biopsy, gastric cancer, screening, prognosis, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), Medicine (General), R5-920 |
| الوصف: | Liquid biopsy represents an exciting new area in the field of cancer diagnosis and management, offering a less invasive and more convenient approach to obtain a time-point image of the tumor burden and its genomic profile. Samples collected from several body fluids, mostly blood, can be used to gain access to circulating tumor cells and DNA, non-coding RNAs, microRNAs, and exosomes, at any moment, offering a dynamic picture of the tumor. For patients with GC, the use of blood-based biopsies may be particularly beneficial since tissue biopsies are difficult to obtain and cause real distress to the patient. With advantages such as repeatability and minimal invasion, it is no wonder that the field of liquid biopsy has received tremendous attention. However, the abundance of studies, involving a wide range of assays with different principles, prevented for the moment the reproducibility of the results and therefore the translation into the clinic of liquid biopsy. In this review, we present the latest technical development and data on circulating biomarkers available through liquid biopsy in gastric cancer with an emphasis on their clinical utility in areas such as cancer screening, prognostic stratification, and therapeutic management. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2296-858X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fmed.2021.749250/full; https://doaj.org/toc/2296-858X |
| DOI: | 10.3389/fmed.2021.749250 |
| URL الوصول: | https://doaj.org/article/e486347330d64d2b86773332f2e50d4c |
| رقم الانضمام: | edsdoj.486347330d64d2b86773332f2e50d4c |
| قاعدة البيانات: | Directory of Open Access Journals |
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