Academic Journal
Conversion to aflibercept for diabetic macular edema unresponsive to ranibizumab or bevacizumab
| العنوان: | Conversion to aflibercept for diabetic macular edema unresponsive to ranibizumab or bevacizumab |
|---|---|
| المؤلفون: | Lim LS, Ng WY, Mathur R, Wong D, Wong EY, Yeo I, Cheung CM, Lee SY, Wong TY, Papakostas TD, Kim LA |
| المصدر: | Clinical Ophthalmology, Vol 2015, Iss default, Pp 1715-1718 (2015) |
| بيانات النشر: | Dove Medical Press, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | Ophthalmology, RE1-994 |
| الوصف: | Laurence S Lim,1,2 Wei Yan Ng,2 Ranjana Mathur,2 Doric Wong,2 Edmund YM Wong,2 Ian Yeo,2 Chui Ming Gemmy Cheung,2 Shu Yen Lee,2 Tien Yin Wong,2 Thanos D Papakostas,1 Leo A Kim1 1Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 2Vitreoretinal Department, Singapore National Eye Centre, Singapore Background: The purpose of this study was to determine if eyes with diabetic macular edema (DME) unresponsive to ranibizumab or bevacizumab would benefit from conversion to aflibercept.Methods: This study was conducted as a retrospective chart review of subjects with DME unresponsive to ranibizumab and/or bevacizumab and subsequently converted to aflibercept.Results: In total, 21 eyes from 19 subjects of mean age 62±15 years were included. The majority of subjects were male (63%). The median number of ranibizumab or bevacizumab injections before switching to aflibercept was six, and the median number of aflibercept injections after switching was three. Median follow-up was 5 months after the switch. Mean central foveal thickness (CFT) was 453.52±143.39 mm immediately prior to the switch. Morphologically, intraretinal cysts were present in all cases. Mean CFT after the first injection decreased significantly to 362.57±92.82 mm (Wilcoxon signed-rank test; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1177-5483 |
| Relation: | https://www.dovepress.com/conversion-to-aflibercept-for-diabeticnbspmacular-edema-unresponsive-t-peer-reviewed-article-OPTH; https://doaj.org/toc/1177-5483 |
| URL الوصول: | https://doaj.org/article/42fdbbd441554552bf18a71e88ed8ae8 |
| رقم الانضمام: | edsdoj.42fdbbd441554552bf18a71e88ed8ae8 |
| قاعدة البيانات: | Directory of Open Access Journals |
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