Academic Journal
Profiles of Endoglin and Vascular Endothelial Growth Factor Based on Staging and Histological Grading of Colorectal Cancer and Their Relationship with Bevacizumab Therapy
| العنوان: | Profiles of Endoglin and Vascular Endothelial Growth Factor Based on Staging and Histological Grading of Colorectal Cancer and Their Relationship with Bevacizumab Therapy |
|---|---|
| المؤلفون: | Rahmawati Minhajat, Sahyuddin Saleh, Tutik Harjianti, Andi Fachruddin Benyamin, A. M. Luthfi Parewangi, Syakib Bakri |
| المصدر: | Journal of Coloproctology, Vol 41, Iss 02, Pp 156-162 (2021) |
| بيانات النشر: | Thieme Revinter Publicações Ltda., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | angiogenesis, bevacizumab, colorectal adenocarcinoma, cd105, vegf, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Objective The present study evaluated the profile of endoglin (CD105) and vascular endothelial growth factor (VEGF) based on staging and histopathological grading of colorectal cancer as well as their relationship with bevacizumab therapy. Methods A total of 88 cases of colorectal adenocarcinoma were included in the present study. The levels of VEGF and CD105 protein were evaluated with enzyme-linked immunosorbent assay (ELISA). Results There was a significant difference in the level of CD105 (p = 0.002) between metastases and non-metastases subjects, showing that CD105 was higher in metastases subjects (4.59 ng/ml). There was no significant difference in the level of VEGF based on the presence of metastasis (p = 0.625). There was a significant difference in the levels of CD105 (p = 0.038) and VEGF (p = 0.010) between the subjects who received chemotherapy and those who did not. The CD105 level was higher in the subjects who received chemotherapy (4.43 ng/ml); conversely, the level of VEGF was lower in subjects who received chemotherapy (543.65 pg/ml). There was a statistically significant difference in the levels of CD105 (p = 0.003) and VEGF (p = 0.002) between subjects who received bevacizumab therapy and subjects who did not. The levels of CD105 were higher in subjects who received bevacizumab therapy (5.11 ng/ml); in contrast, the level of VEGF was higher in subjects who did not receive bevacizumab therapy (645.92 pg/ml). There was a significant positive correlation between CD105 and VEGF in subjects who did not receive bevacizumab (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2237-9363 2317-6423 |
| Relation: | https://doaj.org/toc/2237-9363; https://doaj.org/toc/2317-6423 |
| DOI: | 10.1055/s-0041-1724065 |
| URL الوصول: | https://doaj.org/article/409c39df4c05466382b38a48b8cbf494 |
| رقم الانضمام: | edsdoj.409c39df4c05466382b38a48b8cbf494 |
| قاعدة البيانات: | Directory of Open Access Journals |
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