Academic Journal
Microarray analysis of genes differentially expressed in the liver of lean and fat chickens
| العنوان: | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
|---|---|
| المؤلفون: | H.B. Wang, Q.G. Wang, X.Y. Zhang, X.F. Gu, N. Wang, S.B. Wu, H. Li |
| المصدر: | Animal, Vol 4, Iss 4, Pp 513-522 (2010) |
| بيانات النشر: | Elsevier, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | chicken, liver, gene expression profile, lipid metabolism, Animal culture, SF1-1100 |
| الوصف: | Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver at developmental stages of chicken (1 week, 4 weeks and 7 weeks of age) were investigated and differentially expressed genes between lean and fat chicken lines divergently selected for abdominal fat content for eight generations were screened. Our data indicated that 4 weeks of age was a very important stage on chicken liver lipogenesis compared to 1 week and 7 weeks of age, and the glycometabolism in chicken liver could be related to lipid metabolism and the difference of glycometabolism could be another potential reason for the fat and lean phenotype occurrence besides the difference of lipogenesis in chicken liver. Our result have established groundwork for further study of the basic genetic control of chicken obesity and will benefit chicken research communities as well as researches that use chicken as a model organism for developmental biology and human therapeutics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7311 17517311 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1751731109991388; https://doaj.org/toc/1751-7311 |
| DOI: | 10.1017/S1751731109991388 |
| URL الوصول: | https://doaj.org/article/3f48c54427f44394998c71fa803878ed |
| رقم الانضمام: | edsdoj.3f48c54427f44394998c71fa803878ed |
| قاعدة البيانات: | Directory of Open Access Journals |
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