Academic Journal
Production and characterization of chicken blood hydrolysate with antihypertensive properties
| العنوان: | Production and characterization of chicken blood hydrolysate with antihypertensive properties |
|---|---|
| المؤلفون: | W. Wongngam, T. Mitani, S. Katayama, S. Nakamura, J. Yongsawatdigul |
| المصدر: | Poultry Science, Vol 99, Iss 10, Pp 5163-5174 (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | angiotensin I-converting enzyme (ACE), chicken blood, hypertension, protein hydrolysate, spontaneously hypertensive rat (SHR), Animal culture, SF1-1100 |
| الوصف: | Chicken blood has limited utilization despite its high protein content. Production of a blood hydrolysate exhibiting angiotensin I-converting enzyme (ACE)–inhibitory activity would be means of valorizing chicken blood. The optimized conditions used to produce chicken blood corpuscle hydrolysate (BCH) by Alcalase were 51.1°C, 4% enzyme, and pH 9.6 for 6 h, resulting in a 35.8% degree of hydrolysis and 37.7% ACE inhibition at a peptide concentration of 0.2 mg/mL. The permeate of a 1-kDa membrane, BCH-III, showed a 2.5-fold increase in ACE inhibition compared with that of BCH. BCH-III was resistant to in vitro gastrointestinal digestion, whereas the BCH digesta exhibited an increased ACE-inhibitory activity after digestion. Both BCH and BCH-III were rich in hydrophobic amino acids. A single administration of BCH and BCH-III to spontaneously hypertensive rats at concentrations of 600 and 100 mg/kg, respectively, lowered the systolic blood pressure by −57.7 and −70.9 mmHg, respectively, 6 h after oral administration compared with the control group. The blood pressure–lowering effect of the 600 mg/kg BCH dose was comparable with that of the 100 mg/kg BCH-III dose after 4 wk of oral administration. Both BCH and BCH-III could be developed for use as nutraceutical products with antihypertensive effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0032-5791 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0032579120304533; https://doaj.org/toc/0032-5791 |
| DOI: | 10.1016/j.psj.2020.07.006 |
| URL الوصول: | https://doaj.org/article/3d991c3c9762489d935cfce920213e23 |
| رقم الانضمام: | edsdoj.3d991c3c9762489d935cfce920213e23 |
| قاعدة البيانات: | Directory of Open Access Journals |
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